Immunologic profile of excessive body weight

Mansour Taghavi Azar Sharabiani, Roel Vermeulen, Chiara Scoccianti, Fatemeh Saberi Hosnijeh, Liliana Minelli, Carlotta Sacerdote, Domenico Palli, Vittorio Krogh, Rosario Tumino, Paolo Chiodini, Salvatore Panico, Paolo Vineis

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years. We employed multivariate analysis of variance and a nonparametric Bayesian additive regression tree approach along with a receiver operating characteristic (ROC) curve analysis to determine the immunologic signature of excessive body weight (i.e., obesity and overweight). Interleukin 8 (IL-8), IL-10, interferon γÎ, and inducible protein 10 were shown to be predictive of excessive body weight with an area under the ROC curve of 71% (p

Original languageEnglish
Pages (from-to)243-251
Number of pages9
JournalBiomarkers
Volume16
Issue number3
DOIs
Publication statusPublished - May 2011

Keywords

  • growth factors/cytokines/inflammatory
  • mediators
  • Obesity/diabetes
  • proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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