Immunologic study of vinculin in Duchenne muscular dystrophy

Carlo Minetti, Kurenai Tanji, Eduardo Bonilla

Research output: Contribution to journalArticle

Abstract

Using immunologic techniques, we studied vinculin, a cytoskeletal protein associated with the membrane-skeleton of the muscle fiber. We examined muscle biopsies from five patients with Duchenne muscular dystrophy (DMD), two with Becker's muscular dystrophy (BMD), three normal human muscle samples, and four biopsies from disease control patients. All DMD patients showed patchy and low-intensity immunostain at the sarcolemma of most fibers and, by immunoblot analysis, the content of vinculin was 42 to 61% of control values. There was no significant vinculin deficiency in samples from patients with BMD and other disease controls. The data suggest that vinculin content is reduced only in muscle where dystrophin is absent or sparse.

Original languageEnglish
Pages (from-to)1751-1754
Number of pages4
JournalNeurology
Volume42
Issue number9
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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    Minetti, C., Tanji, K., & Bonilla, E. (1992). Immunologic study of vinculin in Duchenne muscular dystrophy. Neurology, 42(9), 1751-1754.