Immunological abnormalities in intravenous drug abusers and relationship to the prolonged generalized lymphadenopathy syndrome in Italy

P. de Paoli, M. Reitano, S. Battistin, P. Martelli, D. Villalata, F. Bergamo, U. Tirelli, A. Carbone, S. Diodato, R. Bosio

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Abstract

The prolonged generalized lymphadenopathy syndrome (PGL) has been considered a prodromal condition to the acquired immunodeficiency syndrome (AIDS), but the clinical, virological and immunological characteristics of patients who will develop AIDS are not known. We report on the immunological profile of intravenous drug abusers with or without PGL in Northeastern Italy. We found a reduction of lymphocyte-absolute numbers with reversal of the T4/T8 ratio and decreased Leu-11b+ cells. The response to mitogens and natural killer activity are compromised in PGL patients. Neutrophil function is reduced both in drug abusers with or without lymphadenopathy. The serological investigations revealed a high prevalence of antibodies against HTLV III and the Epstein-Barr viruses. The recognition of immune dysfunction in the intravenous drug abusers appears to be important since these patients develop AIDS and these abnormalities may precede AIDS.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalClinical and Experimental Immunology
Volume64
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology

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    de Paoli, P., Reitano, M., Battistin, S., Martelli, P., Villalata, D., Bergamo, F., Tirelli, U., Carbone, A., Diodato, S., & Bosio, R. (1986). Immunological abnormalities in intravenous drug abusers and relationship to the prolonged generalized lymphadenopathy syndrome in Italy. Clinical and Experimental Immunology, 64(3), 451-456.