Immunological and endocrinological response to growth hormone therapy in short children

M. Bozzola, R. Maccario, M. Cisternino, M. De Amici, A. Valtorta, A. Moretta, I. Biscaldi, R. M. Schimpff

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the influence of human growth hormone (hGH) on mitogen-stimulated lymphoproliferation, in vitro IgM production, serum levels of immunoglobulins, somatomedin-C (Sm-C) values and serum growth-promoting activity (Thymidine Activity, TA) in 18 short children, aged between 6.6-14.5 years, undergoing a 3-month course of hGH therapy. Blood was collected the day before treatment (Group A), on the 5th day after patients were administered hGH daily (0.1 U/kg) i.m. for 4 days (Group B), after a 3-month course of hGH injected three times weekly, and finally before (Group C) and 24 h after an extra injection (Group D). In vitro IgM production from the patients' unstimulated lymphocytes decreased from 277 ± 41 (Group A) to 168 ± 38 (Group B), to 119 ± 43 (Group C) and then to 119 ± 28 ng/ml (Group D) (p <0.05). Using PWM-stimulated lymphocytes in vitro IgM production decreased from 2,015 ± 464 (Group A) to 1,116 ± 316 (Group B), then to 511 ± 170 (Group C) and 968 ± 295 ng/ml (Group D) (p <0.02). The variation of this decrease could be correlated with the variation of growth velocity during treatment (r = 0.619, p <0.05). In contrast, no significant changes were found following therapy either in serum levels of IgA, IgE, IgG, IgM, Sm-C and TA, or in phytohemagglutinin, concanavalin A and pokeweed mitogen-stimulated lymphoproliferation. Our data suggest that there is some relationship between growth hormone, growth and immunity.

Original languageEnglish
Pages (from-to)675-680
Number of pages6
JournalActa Paediatrica Scandinavica
Volume77
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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