Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation

E. Donti, B. Falini, P. G. Pelicci, G. Venti Donti, A. Rosetti, M. Martelli, F. Grignani

Research output: Contribution to journalArticle

Abstract

Two sequential lymph node biopsies taken from a non-Hodgkin lymphoma patient revealed two karyotype abnormalities peculiar to B cell neoplasias: trisomy 12 and t(2;8)(p12;q24) translocation. The first was documented in all cells analyzed, while the second was present in 20% of the metaphases from the first biopsy and in 100% from the second. This suggests that the t(2;8) translocation arose as a secondary karyotypic change. In addition, although immunological characterization of the neoplastic cells disclosed a monoclonal B cell population that expressed immunoglobulin κ light chains, as usually found in Burkitt's lymphoma with t(2;8) translocation, Southern blot analysis provided evidence of rearrangement in only one κ chain allele.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalLeukemia
Volume2
Issue number1
Publication statusPublished - 1988

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Chromosomes, Human, Pair 12
Follicular Lymphoma
B-Lymphocytes
Immunoglobulin Light Chains
Biopsy
Burkitt Lymphoma
Trisomy
Metaphase
Southern Blotting
Karyotype
Non-Hodgkin's Lymphoma
Lymph Nodes
Alleles
Population
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

Donti, E., Falini, B., Pelicci, P. G., Venti Donti, G., Rosetti, A., Martelli, M., & Grignani, F. (1988). Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation. Leukemia, 2(1), 41-44.

Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation. / Donti, E.; Falini, B.; Pelicci, P. G.; Venti Donti, G.; Rosetti, A.; Martelli, M.; Grignani, F.

In: Leukemia, Vol. 2, No. 1, 1988, p. 41-44.

Research output: Contribution to journalArticle

Donti, E, Falini, B, Pelicci, PG, Venti Donti, G, Rosetti, A, Martelli, M & Grignani, F 1988, 'Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation', Leukemia, vol. 2, no. 1, pp. 41-44.
Donti, E. ; Falini, B. ; Pelicci, P. G. ; Venti Donti, G. ; Rosetti, A. ; Martelli, M. ; Grignani, F. / Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation. In: Leukemia. 1988 ; Vol. 2, No. 1. pp. 41-44.
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