Abstract
Two sequential lymph node biopsies taken from a non-Hodgkin lymphoma patient revealed two karyotype abnormalities peculiar to B cell neoplasias: trisomy 12 and t(2;8)(p12;q24) translocation. The first was documented in all cells analyzed, while the second was present in 20% of the metaphases from the first biopsy and in 100% from the second. This suggests that the t(2;8) translocation arose as a secondary karyotypic change. In addition, although immunological characterization of the neoplastic cells disclosed a monoclonal B cell population that expressed immunoglobulin κ light chains, as usually found in Burkitt's lymphoma with t(2;8) translocation, Southern blot analysis provided evidence of rearrangement in only one κ chain allele.
| Original language | English |
|---|---|
| Pages (from-to) | 41-44 |
| Number of pages | 4 |
| Journal | Leukemia |
| Volume | 2 |
| Issue number | 1 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Cancer Research
- Hematology
Cite this
Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation. / Donti, E.; Falini, B.; Pelicci, P. G.; Venti Donti, G.; Rosetti, A.; Martelli, M.; Grignani, F.
In: Leukemia, Vol. 2, No. 1, 1988, p. 41-44.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation
AU - Donti, E.
AU - Falini, B.
AU - Pelicci, P. G.
AU - Venti Donti, G.
AU - Rosetti, A.
AU - Martelli, M.
AU - Grignani, F.
PY - 1988
Y1 - 1988
N2 - Two sequential lymph node biopsies taken from a non-Hodgkin lymphoma patient revealed two karyotype abnormalities peculiar to B cell neoplasias: trisomy 12 and t(2;8)(p12;q24) translocation. The first was documented in all cells analyzed, while the second was present in 20% of the metaphases from the first biopsy and in 100% from the second. This suggests that the t(2;8) translocation arose as a secondary karyotypic change. In addition, although immunological characterization of the neoplastic cells disclosed a monoclonal B cell population that expressed immunoglobulin κ light chains, as usually found in Burkitt's lymphoma with t(2;8) translocation, Southern blot analysis provided evidence of rearrangement in only one κ chain allele.
AB - Two sequential lymph node biopsies taken from a non-Hodgkin lymphoma patient revealed two karyotype abnormalities peculiar to B cell neoplasias: trisomy 12 and t(2;8)(p12;q24) translocation. The first was documented in all cells analyzed, while the second was present in 20% of the metaphases from the first biopsy and in 100% from the second. This suggests that the t(2;8) translocation arose as a secondary karyotypic change. In addition, although immunological characterization of the neoplastic cells disclosed a monoclonal B cell population that expressed immunoglobulin κ light chains, as usually found in Burkitt's lymphoma with t(2;8) translocation, Southern blot analysis provided evidence of rearrangement in only one κ chain allele.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023848323&partnerID=8YFLogxK
M3 - Article
C2 - 3339903
AN - SCOPUS:0023848323
VL - 2
SP - 41
EP - 44
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 1
ER -