Immunological and regenerative properties of cord blood stem cells

Roberto Francese, Paolo Fiorina

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Cord blood stem cells (CB-SCs) have shown impressive immunological and regenerative capabilities. In this review, we intend to review the state-of-the-art knowledge on CB-SCs characteristics and function as well as immunological and regenerative properties. We report an itemized classification of CB-SCs populations, which is important to better understand which tissues can be replaced using CB-SCs and how the generation of induced pluripotent stem cells from CB-SCs is changing the field. Furthermore, we will discuss new findings on the immunosuppressive capability of CB-SCs in autoimmune disease (e.g., type 1 diabetes). Our review will demonstrate how CB-SCs could become a powerful tool not only for regenerative medicine but for autoimmune and inflammatory diseases as well.

Original languageEnglish
Pages (from-to)309-322
Number of pages14
JournalClinical Immunology
Volume136
Issue number3
DOIs
Publication statusPublished - Sep 2010

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Fetal Blood
Blood Cells
Stem Cells
Autoimmune Diseases
Induced Pluripotent Stem Cells
Regenerative Medicine
Immunosuppressive Agents
Type 1 Diabetes Mellitus
Population

Keywords

  • Cord blood stem cells
  • Immune regulation
  • Regenerative medicine
  • Transplantation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Immunological and regenerative properties of cord blood stem cells. / Francese, Roberto; Fiorina, Paolo.

In: Clinical Immunology, Vol. 136, No. 3, 09.2010, p. 309-322.

Research output: Contribution to journalArticle

Francese, Roberto ; Fiorina, Paolo. / Immunological and regenerative properties of cord blood stem cells. In: Clinical Immunology. 2010 ; Vol. 136, No. 3. pp. 309-322.
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