Immunological and regenerative properties of cord blood stem cells

Roberto Francese, Paolo Fiorina

Research output: Contribution to journalArticle

Abstract

Cord blood stem cells (CB-SCs) have shown impressive immunological and regenerative capabilities. In this review, we intend to review the state-of-the-art knowledge on CB-SCs characteristics and function as well as immunological and regenerative properties. We report an itemized classification of CB-SCs populations, which is important to better understand which tissues can be replaced using CB-SCs and how the generation of induced pluripotent stem cells from CB-SCs is changing the field. Furthermore, we will discuss new findings on the immunosuppressive capability of CB-SCs in autoimmune disease (e.g., type 1 diabetes). Our review will demonstrate how CB-SCs could become a powerful tool not only for regenerative medicine but for autoimmune and inflammatory diseases as well.

Original languageEnglish
Pages (from-to)309-322
Number of pages14
JournalClinical Immunology
Volume136
Issue number3
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Cord blood stem cells
  • Immune regulation
  • Regenerative medicine
  • Transplantation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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