TY - JOUR
T1 - Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly
T2 - An open-label two-arm trial
AU - Dwyer, Michael G.
AU - Zivadinov, Robert
AU - Tao, Yazhong
AU - Zhang, Xin
AU - Kennedy, Cheryl
AU - Bergsland, Niels
AU - Ramasamy, Deepa P.
AU - Durfee, Jackie
AU - Hojnacki, David
AU - Weinstock-Guttman, Bianca
AU - Hayward, Brooke
AU - Dangond, Fernando
AU - Markovic-Plese, Silva
PY - 2015/11/11
Y1 - 2015/11/11
N2 - Background: Brain volume atrophy is observed in relapsing-remitting multiple sclerosis (RRMS). Methods: Brain volume changes were evaluated in 23 patients with RRMS treated with interferon β-1a 44 μg given subcutaneously (SC) three times a week (tiw) and 15 healthy controls. Percentages of whole brain and tissue-specific volume change were measured from baseline (0 months) to 3 months, from 3 to 6 months, and from baseline to 6 months using SIENAX Multi Time Point (SX-MTP) algorithms. Immunological status of patients was also determined and correlations between subsets of T cells and changes in brain volume were assessed. Results: Interferon β-1a 44 μg SC tiw in 23 patients with RRMS resulted in significant reductions in whole brain and gray matter tissue volume early in the treatment course (baseline to 3 months; mean change; -0.95 %; P = 0.030, -1.52 %; P = 0.004, respectively), suggesting a short-term treatment-induced pseudoatrophy effect. From baseline to 6 months, there were significant correlations observed between decreased T- cell expression of IL-17 F and decreased whole brain and brain tissue-specific volume. Conclusions: These findings are consistent with the interpretation of the pseudoatrophy effect as resolution of inflammation following treatment initiation with interferon β-1a 44 μg SC tiw, rather than disease-related tissue loss. Trial registration: ClinicalTrials.gov; NCT01085318
AB - Background: Brain volume atrophy is observed in relapsing-remitting multiple sclerosis (RRMS). Methods: Brain volume changes were evaluated in 23 patients with RRMS treated with interferon β-1a 44 μg given subcutaneously (SC) three times a week (tiw) and 15 healthy controls. Percentages of whole brain and tissue-specific volume change were measured from baseline (0 months) to 3 months, from 3 to 6 months, and from baseline to 6 months using SIENAX Multi Time Point (SX-MTP) algorithms. Immunological status of patients was also determined and correlations between subsets of T cells and changes in brain volume were assessed. Results: Interferon β-1a 44 μg SC tiw in 23 patients with RRMS resulted in significant reductions in whole brain and gray matter tissue volume early in the treatment course (baseline to 3 months; mean change; -0.95 %; P = 0.030, -1.52 %; P = 0.004, respectively), suggesting a short-term treatment-induced pseudoatrophy effect. From baseline to 6 months, there were significant correlations observed between decreased T- cell expression of IL-17 F and decreased whole brain and brain tissue-specific volume. Conclusions: These findings are consistent with the interpretation of the pseudoatrophy effect as resolution of inflammation following treatment initiation with interferon β-1a 44 μg SC tiw, rather than disease-related tissue loss. Trial registration: ClinicalTrials.gov; NCT01085318
KW - Brain volumetry
KW - Interferon
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Pseudoatrophy
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U2 - 10.1186/s12883-015-0488-9
DO - 10.1186/s12883-015-0488-9
M3 - Article
AN - SCOPUS:84946751053
VL - 15
JO - BMC Neurology
JF - BMC Neurology
SN - 1471-2377
IS - 1
M1 - 232
ER -