Immunological and virological responses in HIV-1 infected adults at early stage of established infection treated with highly active antiretroviral therapy

Pierre Alexandre Bart, G. Paolo Rizzardi, Giuseppe Tambussi, Jean Philippe Chave, Aude G. Chapuis, Cecilia Graziosi, Jean Marc Corpataux, Nermin Halkic, Jean Yves Meuwly, Miguel Munoz, Pascal Meylan, William Spreen, Hugh McDade, Sabine Yerly, Luc Perrin, Adriano Lazzarin, Giuseppe Pantaleo

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the immunological and virological responses to highly active antiretroviral therapy (HAART) in blood and lymphoid compartments of HIV-1-infected patients at an early stage of infection. Design: An open-label, observational, non-randomized, prospective trial of outpatients attending the Centre of Clinical Investigation in Infectious Diseases, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland. Subjects: Forty-one antiretroviral-naive HIV-1-infected adults with 400 CD4 T cells/μl or greater and 5000 plasma HIV-1-RNA copies/ml or greater were enrolled, and 32 finished the study. Forty-nine HIV-negative individuals were included as controls. All subjects gave written informed consent. Interventions: All patients received abacavir 300mg by mouth every 12 h and amprenavir 1200 mg by mouth every 12 h for 72 weeks. Mainoutcome measures: The extent of immune reconstitution in blood and lymph nodes after 72 weeks of HAART was evaluated, and compared with immunological measures of 49 HIV-negative subjects. Results: Virus replication was effectively suppressed (-3.5 log10 at week 72). Substantial increments of CD4 T cell count in blood and percentage in lymph nodes were observed over time, and these measures were comparable to HIV-negative subjects by week 24 in blood and by week 48 in lymph nodes. The increase was equally distributed between naive and memory CD4 T cells. Recovery of HIV-specific CD4 responses occurred in 40% of patients. Conclusion: The initiation of HAART at an early stage of established HIV infection induces systemic quantitative normalization of CD4 T cells, a partial recovery of HIV-specific CD4 cell responses, and effective and durable suppression of virus replication. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)1887-1897
Number of pages11
JournalAIDS (London, England)
Volume14
Issue number13
DOIs
Publication statusPublished - Sep 8 2000

Keywords

  • Early established infection
  • HAART
  • HIV
  • HIV-specific CD4 cell responses
  • Immune reconstitution
  • Lymph node
  • Plasma viraemia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Bart, P. A., Rizzardi, G. P., Tambussi, G., Chave, J. P., Chapuis, A. G., Graziosi, C., Corpataux, J. M., Halkic, N., Meuwly, J. Y., Munoz, M., Meylan, P., Spreen, W., McDade, H., Yerly, S., Perrin, L., Lazzarin, A., & Pantaleo, G. (2000). Immunological and virological responses in HIV-1 infected adults at early stage of established infection treated with highly active antiretroviral therapy. AIDS (London, England), 14(13), 1887-1897. https://doi.org/10.1097/00002030-200009080-00002