Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy?

Ernesto Rossi; Giovanni Schinzari; Ilaria Grazia Zizzari; Brigida Anna Maiorano; Monica Maria Pagliara; Maria Grazia Sammarco; Vincenzo Fiorentino; Gianluigi Petrone; Alessandra Cassano; Guido Rindi; Emilio Bria; Maria Antonietta Blasi; Marianna Nuti; Giampaolo Tortora

doi:10.3390/cancers11081055

Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy?

Ernesto Rossi, Giovanni Schinzari, Ilaria Grazia Zizzari, Brigida Anna Maiorano, Monica Maria Pagliara, Maria Grazia Sammarco, Vincenzo Fiorentino, Gianluigi Petrone, Alessandra Cassano, Guido Rindi, Emilio Bria, Maria Antonietta Blasi, Marianna Nuti, Giampaolo Tortora

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Review article

Abstract

No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease.

Original language	English
Journal	Cancers
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/cancers11081055
Publication status	Published - Jul 26 2019

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Rossi, E., Schinzari, G., Zizzari, I. G., Maiorano, B. A., Pagliara, M. M., Sammarco, M. G., Fiorentino, V., Petrone, G., Cassano, A., Rindi, G., Bria, E., Blasi, M. A., Nuti, M., & Tortora, G. (2019). Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? Cancers, 11(8). https://doi.org/10.3390/cancers11081055

Immunological Backbone of Uveal Melanoma : Is There a Rationale for Immunotherapy? / Rossi, Ernesto; Schinzari, Giovanni; Zizzari, Ilaria Grazia; Maiorano, Brigida Anna; Pagliara, Monica Maria; Sammarco, Maria Grazia; Fiorentino, Vincenzo; Petrone, Gianluigi; Cassano, Alessandra; Rindi, Guido ; Bria, Emilio; Blasi, Maria Antonietta; Nuti, Marianna; Tortora, Giampaolo.

In: Cancers, Vol. 11, No. 8, 26.07.2019.

Research output: Contribution to journal › Review article

Rossi, Ernesto ; Schinzari, Giovanni ; Zizzari, Ilaria Grazia ; Maiorano, Brigida Anna ; Pagliara, Monica Maria ; Sammarco, Maria Grazia ; Fiorentino, Vincenzo ; Petrone, Gianluigi ; Cassano, Alessandra ; Rindi, Guido ; Bria, Emilio ; Blasi, Maria Antonietta ; Nuti, Marianna ; Tortora, Giampaolo. / Immunological Backbone of Uveal Melanoma : Is There a Rationale for Immunotherapy?. In: Cancers. 2019 ; Vol. 11, No. 8.

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title = "Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy?",

abstract = "No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease.",

author = "Ernesto Rossi and Giovanni Schinzari and Zizzari, {Ilaria Grazia} and Maiorano, {Brigida Anna} and Pagliara, {Monica Maria} and Sammarco, {Maria Grazia} and Vincenzo Fiorentino and Gianluigi Petrone and Alessandra Cassano and Guido Rindi and Emilio Bria and Blasi, {Maria Antonietta} and Marianna Nuti and Giampaolo Tortora",

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T2 - Is There a Rationale for Immunotherapy?

AU - Rossi, Ernesto

AU - Schinzari, Giovanni

AU - Zizzari, Ilaria Grazia

AU - Maiorano, Brigida Anna

AU - Pagliara, Monica Maria

AU - Sammarco, Maria Grazia

AU - Fiorentino, Vincenzo

AU - Petrone, Gianluigi

AU - Cassano, Alessandra

AU - Rindi, Guido

AU - Bria, Emilio

AU - Blasi, Maria Antonietta

AU - Nuti, Marianna

AU - Tortora, Giampaolo

PY - 2019/7/26

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N2 - No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease.

AB - No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease.

U2 - 10.3390/cancers11081055

DO - 10.3390/cancers11081055

M3 - Review article

C2 - 31357439

VL - 11

JO - Cancers

JF - Cancers

SN - 2072-6694

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ER -

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Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy?

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FONDAZIONE GEMELLI - Ricerca Traslazionale nella Medicina Personalizzata delle malattie croniche complesse