Immunological basis of virus-host interaction in COVID-19: Pediatric Allergy and Immunology

F. La Torre, L. Leonardi, G. Giardino, S. Volpi, S. Federici, A. Soresina, C. Cancrini, V. Lougaris, R. Castagnoli, S. Corrente, F. Cardinale, Immunology (SIAIP) the Immunology Commission of the Italian Society of Pediatric Allergy

Research output: Contribution to journalArticlepeer-review

Abstract

COVID-19 is a complex new viral disease, in which a strict balance between anti-viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, age-related susceptibility, and the capability to mount appropriate immune responses might play a role in control virus load at an early stage and regulating the inflammatory reaction. Elucidating these mechanisms seems crucial in developing target therapies according to patient's age, immunologic status, and disease evolution in COVID-19. © 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd
Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalPediatr. Allergy Immunol.
Volume31
Issue numberS26
DOIs
Publication statusPublished - 2020

Keywords

  • children
  • COVID-19
  • cytokine storm
  • immunopathogenesis
  • Kawasaki disease
  • complication
  • cytokine release syndrome
  • etiology
  • human
  • immunology
  • pneumonia
  • Cytokine Release Syndrome
  • Host Microbial Interactions
  • Humans
  • Pneumonia
  • SARS-CoV-2

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