The purpose of the present study was to compare IgD and IgM levels of the serum, saliva and nasal secretions and IgG levels of the serum in a group of 14 children with selective IgA deficiency and in a group of 12 sex and age matched healthy controls, using a highly sensitive ELISA technique. Like IgM, serum IgD levels were significantly higher than secretory IgD levels, and IgD was present in greater concentrations in nasal secretions than in saliva both in the patients and the controls, with no difference between the two groups. In the IgA deficient children serum IgG and IgM and secretory IgM were present in higher concentrations than in the controls, but the difference was statistically significant only for serum IgG and salivary IgM. On the contrary, no difference was observed between IgD levels in serum, saliva and nasal secretions of the IgA deficient children and controls. These data support the hypothesis of a compensatory increase of IgM, but not of IgD, in subjects with selective IgA deficiency. No correlation was found between clinical manifestations presented by our patients, in particular upper respiratory tract infections, and the immunoglobulin levels in serum and secretions.
|Translated title of the contribution||Immunological characteristics of nasal secretions and saliva in children with selective IgA deficiency|
|Number of pages||5|
|Journal||Rivista Italiana di Otorinolaringologia Audiologia e Foniatria|
|Publication status||Published - 1985|
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