Immunological, clinical and epidemiological aspects of an HIV-1 positive drug abuser cohort

I. Mezzaroma, G. D'Offizi, E. Pinter, R. Ferrara, R. Rosso, E. Guerra, G. Ricci, M. Carta, S. Angelini, F. Aiuti

Research output: Contribution to journalArticlepeer-review


We analyzed a cohort of intravenous drug abusers with HIV-1 disease attending our institute in the years 1985-1993. We focused particular attention on the epidemiological analysis of patients, and their clinical, immunological and infectious conditions. The significance of biological markers, particulary CD4+ lymphocyte count and the occurence of other viral infections such as Cytomegalovirus, Epstein-Barr virus, Herpes Simplex virus and Hepatitis B and C viruses in the progress of HIV-1 disease were evaluated. At least two-thirds of the patients at different stages of HIV-1 were treated with antiretroviral drugs: zidovudine (AZT) from 1987 up to the present and more recently didanosine (DDI) alone or in combination with AZT. Psychological and behavioral aspects of our HIV-1 infected drug abusers, in particular needle exchange and condom use, were analyzed.

Original languageEnglish
Pages (from-to)657-672
Number of pages16
JournalJournal of Drug Issues
Issue number4
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pathology and Forensic Medicine
  • Health(social science)


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