Immunological comorbity in coeliac disease: Associations, risk factors and clinical implications

Luca Elli, Antonella Bonura, Daniela Garavaglia, Eliana Rulli, Irene Floriani, Giovanna Tagliabue, Paolo Contiero, Maria Teresa Bardella

Research output: Contribution to journalArticlepeer-review


Purpose: Coeliac disease is frequently associated with other immunomediated diseases. Our aim was to identify immunological comorbidities and possible risk factors for their development in coeliac patients. Methods: We recruited a cohort of 1,015 coeliac patients followed from 0 to 46 years in a single tertiary referral centre. Data were collected from the yearly scheduled clinical and serological evaluations. Possible risk factors such as demographic parameters, type of symptomatic presentation, gluten exposure, gluten-free diet compliance and family history were all evaluated. Subjects (848,606) from the regional health registry were investigated as controls. Results: The prevalence of immunomediated diseases was higher in patients with coeliac disease compared to the registry population (23 % vs 0.4 %, p

Original languageEnglish
Pages (from-to)984-990
Number of pages7
JournalJournal of Clinical Immunology
Issue number5
Publication statusPublished - Oct 2012


  • Antibodies
  • Coeliac disease
  • Gluten free diet
  • Immunomediated disorder

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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