Immunological effects following administration of interferon-α in patients with chronic hepatitis C virus (cHCV) infection.

Emilio Jirillo, Beatrice Greco, Luigi Caradonna, Rosa Satalino, Luigi Amati, Raffaele Cozzolongo, Renato Cuppone, Onofrio G. Manghisi

Research output: Contribution to journalArticle

Abstract

The immunological effects of interferon (IFN)-α administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-α three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 subjects) and nonresponders (3 subjects), respectively, according to alanine aminotransferase serum levels at the end of treatment. Before therapy (T0), absolute numbers of CD3+, CD4+, CD8+, CD14+ and CD16+ cells were significantly reduced in both groups when compared to normal values. At the same time, all patients displayed a profound decrease of phagocytosis and killing exerted by both polymorphonuclear cells (PMN) and monocytes (MO). However, MO Killing resulted to be normal in the responder group. With special reference to T cell function, T cell mediated antibacterial activity, using Salmonella typhi as a target, was also significantly reduced. After therapy (T12), in responder patients a significant increase of CD3+, CD4+ CD14+ and CD16+ cell absolute numbers was observed, while phagocytic and T cell functions were still depressed. Among the nonresponders, in two of three patients IFN-α administration gave rise to an increase (above normality) of CD3+, CD4+, CD8+, CD14+, CD16+ and CD20+ cell absolute numbers, while in one patient the same markers dramatically dropped below normal range. In two patients, antibacterial activity was significantly augmented by IFN-αtreatment, whereas in one patient no modification was observed. Finally, in the same patients IFN-α did not correct PMN and MO pretreatment deficits.

Original languageEnglish
Pages (from-to)355-374
Number of pages20
JournalImmunopharmacology and Immunotoxicology
Volume18
Issue number3
Publication statusPublished - 1996

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Chronic Hepatitis C
Virus Diseases
Viruses
Hepacivirus
Interferons
T-cells
Salmonella
Monocytes
Alanine Transaminase
Interferon-alpha
T-Lymphocytes
Reference Values
Cell Count
Salmonella typhi
Therapeutics
Phagocytes
Phagocytosis
Serum

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Immunology
  • Pharmacology
  • Toxicology

Cite this

Immunological effects following administration of interferon-α in patients with chronic hepatitis C virus (cHCV) infection. / Jirillo, Emilio; Greco, Beatrice; Caradonna, Luigi; Satalino, Rosa; Amati, Luigi; Cozzolongo, Raffaele; Cuppone, Renato; Manghisi, Onofrio G.

In: Immunopharmacology and Immunotoxicology, Vol. 18, No. 3, 1996, p. 355-374.

Research output: Contribution to journalArticle

Jirillo, E, Greco, B, Caradonna, L, Satalino, R, Amati, L, Cozzolongo, R, Cuppone, R & Manghisi, OG 1996, 'Immunological effects following administration of interferon-α in patients with chronic hepatitis C virus (cHCV) infection.', Immunopharmacology and Immunotoxicology, vol. 18, no. 3, pp. 355-374.
Jirillo, Emilio ; Greco, Beatrice ; Caradonna, Luigi ; Satalino, Rosa ; Amati, Luigi ; Cozzolongo, Raffaele ; Cuppone, Renato ; Manghisi, Onofrio G. / Immunological effects following administration of interferon-α in patients with chronic hepatitis C virus (cHCV) infection. In: Immunopharmacology and Immunotoxicology. 1996 ; Vol. 18, No. 3. pp. 355-374.
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