Abstract
Diffuse connective tissue diseases (DCTD) represent an heterogeneous group of disorders characterized by systemic inflammatory reactions that are currently classified on clinical grounds. Their aetiopathogenesis is largely unknown and appears to be very complex, associating exogenous factors with an immunogenetic predisposition. In the last decade, studies on human leukocyte antigen (HLA)-disease associations and antinuclear antibodies have provided some useful clues for the diagnosis and clinical management of DCTD.
Original language | English |
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Pages (from-to) | 224-231 |
Number of pages | 8 |
Journal | European Journal of Pediatrics |
Volume | 149 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jan 1990 |
Keywords
- Antinuclear antibodies
- Diffuse connective tissue diseases
- Human leukocyte antigens (HLA)
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health