Immunological functions of leptin and adiponectin

Fortunata Carbone, Claudia La Rocca, Giuseppe Matarese

Research output: Contribution to journalArticlepeer-review

Abstract

Recent years have seen several advances in our understanding of the functions of adipose tissue regarding not only the energy storage, but also the regulation of complex metabolic and endocrine functions. In this context, leptin and adiponectin, the two most abundant adipocyte products, represent one of the best example of adipocytokines involved in the control of energy expenditure, lipid and carbohydrate metabolism as well as in the regulation of immune responses. Leptin and adiponectin secretion is counter-regulated in vivo, in relation to degree of adiposity, since plasma leptin concentrations are significantly elevated in obese subjects in proportion to body mass index while adiponectin secretion decreases in relation to the amount of adipose tissue. In this review we focus on the main biological activities of leptin and adiponectin on the lipid and carbohydrate metabolism and on their contribute in regulation of innate and adaptive immune responses.

Original languageEnglish
Pages (from-to)2082-2088
Number of pages7
JournalBiochimie
Volume94
Issue number10
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Adaptive immunity
  • Adipocytokines
  • Autoimmunity
  • Innate immunity

ASJC Scopus subject areas

  • Biochemistry

Fingerprint

Dive into the research topics of 'Immunological functions of leptin and adiponectin'. Together they form a unique fingerprint.

Cite this