Immunological heterogeneity of haemophilia B

A multicentre study of 98 kindreds

V. R. Parekh, P. M. Mannucci, Z. M. Ruggeri

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

An electroimmunoassay with a precipitating rabbit anti-human factor IX antiserum and an inhibitor neutralization assay with a non-precipitating homologous antibody were used to measure factor IX antigen (IX:Ag) in 117 patients from 98 kindreds with haemophilia B; and to investigate in a mixed population the incidence of different immunological types of the disease. Although the two assays showed an excellent correlation, the electroimmunoassay was selected for its simplicity as a criterion for classification. 52 kindreds, referred to as haemophilia B-, were characterized by severe deficiency of factor IX coagulant activity (

Original languageEnglish
Pages (from-to)643-655
Number of pages13
JournalBritish Journal of Haematology
Volume40
Issue number4
Publication statusPublished - 1978

Fingerprint

Hemophilia B
Multicenter Studies
Factor IX
Coagulants
Immune System Diseases
Immune Sera
Rabbits
Antigens
Antibodies
Incidence
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Immunological heterogeneity of haemophilia B : A multicentre study of 98 kindreds. / Parekh, V. R.; Mannucci, P. M.; Ruggeri, Z. M.

In: British Journal of Haematology, Vol. 40, No. 4, 1978, p. 643-655.

Research output: Contribution to journalArticle

@article{07b605ed57844713ac2de0afe2242004,
title = "Immunological heterogeneity of haemophilia B: A multicentre study of 98 kindreds",
abstract = "An electroimmunoassay with a precipitating rabbit anti-human factor IX antiserum and an inhibitor neutralization assay with a non-precipitating homologous antibody were used to measure factor IX antigen (IX:Ag) in 117 patients from 98 kindreds with haemophilia B; and to investigate in a mixed population the incidence of different immunological types of the disease. Although the two assays showed an excellent correlation, the electroimmunoassay was selected for its simplicity as a criterion for classification. 52 kindreds, referred to as haemophilia B-, were characterized by severe deficiency of factor IX coagulant activity (",
author = "Parekh, {V. R.} and Mannucci, {P. M.} and Ruggeri, {Z. M.}",
year = "1978",
language = "English",
volume = "40",
pages = "643--655",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "4",

}

TY - JOUR

T1 - Immunological heterogeneity of haemophilia B

T2 - A multicentre study of 98 kindreds

AU - Parekh, V. R.

AU - Mannucci, P. M.

AU - Ruggeri, Z. M.

PY - 1978

Y1 - 1978

N2 - An electroimmunoassay with a precipitating rabbit anti-human factor IX antiserum and an inhibitor neutralization assay with a non-precipitating homologous antibody were used to measure factor IX antigen (IX:Ag) in 117 patients from 98 kindreds with haemophilia B; and to investigate in a mixed population the incidence of different immunological types of the disease. Although the two assays showed an excellent correlation, the electroimmunoassay was selected for its simplicity as a criterion for classification. 52 kindreds, referred to as haemophilia B-, were characterized by severe deficiency of factor IX coagulant activity (

AB - An electroimmunoassay with a precipitating rabbit anti-human factor IX antiserum and an inhibitor neutralization assay with a non-precipitating homologous antibody were used to measure factor IX antigen (IX:Ag) in 117 patients from 98 kindreds with haemophilia B; and to investigate in a mixed population the incidence of different immunological types of the disease. Although the two assays showed an excellent correlation, the electroimmunoassay was selected for its simplicity as a criterion for classification. 52 kindreds, referred to as haemophilia B-, were characterized by severe deficiency of factor IX coagulant activity (

UR - http://www.scopus.com/inward/record.url?scp=0018077058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018077058&partnerID=8YFLogxK

M3 - Article

VL - 40

SP - 643

EP - 655

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 4

ER -