Immunological heterogeneity of haemophilia B: A multicentre study of 98 kindreds

V. R. Parekh, P. M. Mannucci, Z. M. Ruggeri

Research output: Contribution to journalArticlepeer-review


An electroimmunoassay with a precipitating rabbit anti-human factor IX antiserum and an inhibitor neutralization assay with a non-precipitating homologous antibody were used to measure factor IX antigen (IX:Ag) in 117 patients from 98 kindreds with haemophilia B; and to investigate in a mixed population the incidence of different immunological types of the disease. Although the two assays showed an excellent correlation, the electroimmunoassay was selected for its simplicity as a criterion for classification. 52 kindreds, referred to as haemophilia B-, were characterized by severe deficiency of factor IX coagulant activity (

Original languageEnglish
Pages (from-to)643-655
Number of pages13
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Hematology


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