Immunological markers in the cerebrospinal fluid of HIV-1-infected children

P. Gallo, A. M. Laverda, A. De Rossi, S. Pagni, A. Del Mistro, P. Cogo, M. G. Piccinno, A. Plebani, B. Tavolato, L. Chieco-Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

Several immunological abnormalities were detected in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected children. Intrathecal synthesis of immunoglobulins, free light chains (FLC), IL-1β, IL-6, and M-CSF were demonstrated both in asymptomatic children and children with subacute encephalopathy. Our findings further support the hypothesis that an immunopathological subclinical process within the central nervous system (CNS) may be an early manifestation of acquired immunodeficiency syndrome (AIDS). Cytokine detection in the CSF may represent a useful diagnostic tool in evaluating the outcome of HIV-1-infected patients.

Original languageEnglish
Pages (from-to)659-666
Number of pages8
JournalActa Paediatrica Scandinavica
Volume80
Issue number6-7
Publication statusPublished - 1991

Keywords

  • cerebrospinal fluid
  • children
  • cytokines
  • HIV-1

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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