Immunological mechanisms underlying chronic rhinosinusitis with nasal polyps

Enrico Heffler, Luca Malvezzi, Monica Boita, Luisa Brussino, Armando De Virgilio, Matteo Ferrando, Francesca Puggioni, Francesca Racca, Niccolò Stomeo, Giuseppe Spriano, Giorgio Walter Canonica

Research output: Contribution to journalReview article

Abstract

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common and quality-of-life impacting disorder, with an underlying immunological mechanism similar to other conditions such as eosinophilic asthma or atopic eczema. Areas covered: This review article summarizes the most recent evidence on the main immunological mechanisms involved in the pathogenesis and the perpetuation of CRSwNP, with a particular focus on the key role of epithelium-derived inflammation as a consequence of the interaction with the airborne environment. Expert commentary: The increase in knowledge of the immunology of CRSwNP leads to the development of therapeutical strategies based upon the use of biologic agents that, according to a personalized and precision medicine approach, will provide each single patient with the most suitable immunological treatment.

Original languageEnglish
Pages (from-to)731-737
Number of pages7
JournalExpert Review of Clinical Immunology
Volume14
Issue number9
DOIs
Publication statusPublished - Sep 2 2018

Keywords

  • Chronic rhinosinusitis
  • epithelium
  • immunology
  • inflammation
  • nasal polyps

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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