Immunological Patterns during Regular Intensive Training in Athletes: Quantification and Evaluation of a Preventive Pharmacological Approach

U. Garagiola, M. Buzzetti, E. Cardella, F. Confalonieri, E. Giani, V. Polin, P. Ferrante, R. Mancuso, M. Montanari, E. Gross, A. Pecori

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of regular intensive exercise training on immune system homeostasis and the potential value of treatment with an immunostimulating agent were assessed in this randomized, double-blind, placebo-controlled, parallel-group study. A total of 60 athletes were studied over a 3-month period of regular intensive physical activity. After 1 and 3 months there were significant decreases in the immunoglobulin levels in the whole athlete population compared with baseline values. Specifically there were significant decreases in immunoglobulin M and immunoglobulin G (G1 and G2 subclasses). There was also a significant decrease in natural killer cells and a slight but significant increase in B and T lymphocytes. In the thymomodulin-treated group, unlike the placebo group, there was no significant decrease in the immunoglobulin G2 subclass and there was a significant increase in the T-helper cell subpopulation. The clinical relevance of these immunological findings should be evaluated in larger clinical and epidemiological studies.

Original languageEnglish
Pages (from-to)85-95
Number of pages11
JournalJournal of International Medical Research
Volume23
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • Exercise
  • Immunity
  • Immunoglobulins
  • Lymphocyte Subpopulations
  • Thymomodulin

ASJC Scopus subject areas

  • Medicine(all)
  • Cell Biology
  • Biochemistry, medical
  • Biochemistry

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