Immunological Patterns during Regular Intensive Training in Athletes

Quantification and Evaluation of a Preventive Pharmacological Approach

U. Garagiola, M. Buzzetti, E. Cardella, F. Confalonieri, E. Giani, V. Polin, P. Ferrante, R. Mancuso, M. Montanari, E. Gross, A. Pecori

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of regular intensive exercise training on immune system homeostasis and the potential value of treatment with an immunostimulating agent were assessed in this randomized, double-blind, placebo-controlled, parallel-group study. A total of 60 athletes were studied over a 3-month period of regular intensive physical activity. After 1 and 3 months there were significant decreases in the immunoglobulin levels in the whole athlete population compared with baseline values. Specifically there were significant decreases in immunoglobulin M and immunoglobulin G (G1 and G2 subclasses). There was also a significant decrease in natural killer cells and a slight but significant increase in B and T lymphocytes. In the thymomodulin-treated group, unlike the placebo group, there was no significant decrease in the immunoglobulin G2 subclass and there was a significant increase in the T-helper cell subpopulation. The clinical relevance of these immunological findings should be evaluated in larger clinical and epidemiological studies.

Original languageEnglish
Pages (from-to)85-95
Number of pages11
JournalJournal of International Medical Research
Volume23
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Athletes
Immunoglobulins
Placebos
Pharmacology
Exercise
T-cells
Immune system
Helper-Inducer T-Lymphocytes
Natural Killer Cells
Immunoglobulin M
Epidemiologic Studies
Immune System
Homeostasis
B-Lymphocytes
Immunoglobulin G
T-Lymphocytes
Population
Therapeutics
thymomodulin
Clinical Studies

Keywords

  • Exercise
  • Immunity
  • Immunoglobulins
  • Lymphocyte Subpopulations
  • Thymomodulin

ASJC Scopus subject areas

  • Medicine(all)
  • Cell Biology
  • Biochemistry, medical
  • Biochemistry

Cite this

Immunological Patterns during Regular Intensive Training in Athletes : Quantification and Evaluation of a Preventive Pharmacological Approach. / Garagiola, U.; Buzzetti, M.; Cardella, E.; Confalonieri, F.; Giani, E.; Polin, V.; Ferrante, P.; Mancuso, R.; Montanari, M.; Gross, E.; Pecori, A.

In: Journal of International Medical Research, Vol. 23, No. 2, 1995, p. 85-95.

Research output: Contribution to journalArticle

Garagiola, U, Buzzetti, M, Cardella, E, Confalonieri, F, Giani, E, Polin, V, Ferrante, P, Mancuso, R, Montanari, M, Gross, E & Pecori, A 1995, 'Immunological Patterns during Regular Intensive Training in Athletes: Quantification and Evaluation of a Preventive Pharmacological Approach', Journal of International Medical Research, vol. 23, no. 2, pp. 85-95. https://doi.org/10.1177/030006059502300201
Garagiola, U. ; Buzzetti, M. ; Cardella, E. ; Confalonieri, F. ; Giani, E. ; Polin, V. ; Ferrante, P. ; Mancuso, R. ; Montanari, M. ; Gross, E. ; Pecori, A. / Immunological Patterns during Regular Intensive Training in Athletes : Quantification and Evaluation of a Preventive Pharmacological Approach. In: Journal of International Medical Research. 1995 ; Vol. 23, No. 2. pp. 85-95.
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