Immunological patterns identifying disease course and evolution in multiple sclerosis patients

Roberto Furlan, Marco Rovaris, Filippo Martinelli Boneschi, Mohsen Khademi, Alessandra Bergami, Maira Gironi, Michela Deleidi, Federica Agosta, Diego Franciotta, Elio Scarpini, Antonio Uccelli, Mauro Zaffaroni, Asli Kurne, Giancarlo Comi, Tomas Olsson, Massimo Filippi, Gianvito Martino

Research output: Contribution to journalArticlepeer-review

Abstract

Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS patients. The combined measurement of mRNA levels of IL-1β, TNF-α, TGF-β, CCL20 and CCR3 was able to distinguish MS patients from healthy individuals. CXCR5, CCL5, and CCR3 combined mRNA levels identify primary progressive MS patients while TNF-α, IL-10, CXCL10 and CCR3 differentiate relapsing MS patients. Our results indicate that multi-parametric analysis of mRNA levels of immunological relevant molecules in PBMCs may represent a successful strategy for the identification of putative peripheral markers of disease state and disease activity in MS patients.

Original languageEnglish
Pages (from-to)192-200
Number of pages9
JournalJournal of Neuroimmunology
Volume165
Issue number1-2
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Chemokines
  • Cytokines
  • Multiple sclerosis
  • Multivariate analysis
  • Real-time RT-PCR

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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