Immunological prevention of spontaneous tumors: A new prospect?

Elena Quaglino, Stefania Rovero, Federica Cavallo, Piero Musiani, Augusto Amici, Giordano Nicoletti, Patrizia Nanni, Guido Forni

Research output: Contribution to journalArticle

Abstract

Recent demonstrations of the specific immune prevention of mammary cancer in female BALB/c mice transgenic for the rat Her-2/neu oncogene (BALB-neuT) have resulted in reconsideration of the immune mechanisms that inhibit tumor growth. All the mammary glands of these mice progress asynchronously, but consistently, from hyperplasia to invasive carcinoma. Overexpression of the oncogene product p185neu is first evident in the rudimentary glands of 3-week-old mice. Carcinogenesis is prevented by vaccination with plasmids coding for the extracellular and transmembrane domains of this p185neu, or with allogeneic cells expressing p185neu on their membrane, plus the systemic administration of IL-12. This inhibition is the outcome of a delayed-type hypersensitivity specific for p185neu and the production of anti-p185neu antibodies that restrain the proliferation of tumor cells by stripping p185neu from their membrane, whereas cytotoxic T lymphocytes seem devoid of a major role.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalImmunology Letters
Volume80
Issue number2
DOIs
Publication statusPublished - Feb 1 2002

Keywords

  • Breast carcinoma
  • Her-2/neu
  • Immunity
  • Prevention

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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  • Cite this

    Quaglino, E., Rovero, S., Cavallo, F., Musiani, P., Amici, A., Nicoletti, G., Nanni, P., & Forni, G. (2002). Immunological prevention of spontaneous tumors: A new prospect? Immunology Letters, 80(2), 75-79. https://doi.org/10.1016/S0165-2478(01)00323-6