Immunological stress in kidney cancer patients undergoing either open nephrectomy or nephron-sparing surgery: An immunophenotypic study of lymphocyte subpopulations and circulating dendritic cells

Camillo Porta, Lucia Bonomi, Beatrice Lillaz, Catherine Klersy, Ilaria Imarisio, Chiara Paglino, Bianca Rovati, Marco Danova, Elisa Ferraris, Mario Mensi, Bruno Rovereto

Research output: Contribution to journalArticle

Abstract

Immunosuppression is a characteristic hallmark of renal cell carcinoma (RCC), with several complex immune defects, almost solely at the level of cell-mediated immune function, well evident even in patients at first diagnosis. The main circulating lymphocyte subsets and the total number of circulating dendritic cells were quantified in 47 RCC patients at diagnosis (T0), 12 h (T1), 24 h (T2) and 8 days following either radical nephrectomy or nephron-sparing surgery using flow cytometry. RCC patients presented, at baseline, (T0) a profound state of immunosuppression involving naïve T-cells, memory T-cells, CD16+ NK and total circulating dendritic cells, that worsened after 12 (T1) and 24 h (T2) from surgery, involving the majority of the analysed subsets; after 8 days (T3) from surgical removal of tumor, however, there was a return of all the analyzed parameters to the basal state. In conclusion, surgery causes transient but relevant immune suppression in RCC patients; even though, by day +8, this tends to return to baseline, immunostimulatory therapies could be considered in the peri-operative setting with the aim of reducing immunosuppression and, hopefully, also disease recurrence.

Original languageEnglish
Pages (from-to)1511-1519
Number of pages9
JournalOncology Reports
Volume20
Issue number6
DOIs
Publication statusPublished - 2008

Fingerprint

Kidney Neoplasms
Nephrons
Lymphocyte Subsets
Nephrectomy
Renal Cell Carcinoma
Dendritic Cells
Immunosuppression
T-Lymphocytes
Antigen-Antibody Complex
Flow Cytometry
Recurrence
Neoplasms
Therapeutics

Keywords

  • Dendritic cells
  • Immunosuppression
  • Lymphocyte subpopulations
  • Renal cell carcinoma
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Immunological stress in kidney cancer patients undergoing either open nephrectomy or nephron-sparing surgery: An immunophenotypic study of lymphocyte subpopulations and circulating dendritic cells",
abstract = "Immunosuppression is a characteristic hallmark of renal cell carcinoma (RCC), with several complex immune defects, almost solely at the level of cell-mediated immune function, well evident even in patients at first diagnosis. The main circulating lymphocyte subsets and the total number of circulating dendritic cells were quantified in 47 RCC patients at diagnosis (T0), 12 h (T1), 24 h (T2) and 8 days following either radical nephrectomy or nephron-sparing surgery using flow cytometry. RCC patients presented, at baseline, (T0) a profound state of immunosuppression involving na{\"i}ve T-cells, memory T-cells, CD16+ NK and total circulating dendritic cells, that worsened after 12 (T1) and 24 h (T2) from surgery, involving the majority of the analysed subsets; after 8 days (T3) from surgical removal of tumor, however, there was a return of all the analyzed parameters to the basal state. In conclusion, surgery causes transient but relevant immune suppression in RCC patients; even though, by day +8, this tends to return to baseline, immunostimulatory therapies could be considered in the peri-operative setting with the aim of reducing immunosuppression and, hopefully, also disease recurrence.",
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T1 - Immunological stress in kidney cancer patients undergoing either open nephrectomy or nephron-sparing surgery

T2 - An immunophenotypic study of lymphocyte subpopulations and circulating dendritic cells

AU - Porta, Camillo

AU - Bonomi, Lucia

AU - Lillaz, Beatrice

AU - Klersy, Catherine

AU - Imarisio, Ilaria

AU - Paglino, Chiara

AU - Rovati, Bianca

AU - Danova, Marco

AU - Ferraris, Elisa

AU - Mensi, Mario

AU - Rovereto, Bruno

PY - 2008

Y1 - 2008

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