Immunological studies in patients with central nervous system tumors

L. Palmas, Viviana Moschese, Elena Galli, Concetta Barbieri, V. R M Lombardi, P. Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Impairment of cell-mediated immunity in patients with primary central nervous system (CNS) tumors has repeatedly been reported but data to demonstrate the undelying immunological defect are not univocal. This report concerns a series of 31 patients harboring a glioma in which we studied: 1) peripheral blood Tlymphocyte subpopulations by monoclonal antibody analysis; 2) cellular responsiveness to mitogens 3) serum immunoglobulin values. The same parameters were also evaluated in 7 cases of intracranial meningioma and in 8 patients affected by non-proliferative, non-inflammatory CNS diseases. Thirty age-matched healthy volunteers formed the control group. Neither impairment of Tcells as regard to number, responsiveness and subsets, nor abnormal Ig values were found in these groups. However two patients, harboring respectively a third ventricle low grade astrocytoma and an anterior callosal glioblastoma, presented a striking Tcells impairment. These findings might suggest a correlation between hypothalamus and immune system, as already postulated by several previous experimental and clinical studies.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalJournal of Neuro-Oncology
Volume5
Issue number1
DOIs
Publication statusPublished - Mar 1987

Keywords

  • brain tumors
  • monoclonal antibodies
  • T-cell subsets

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

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