Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1190-1201 |
| Number of pages | 12 |
| Journal | J. Crohn's Colitis |
| Volume | 14 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2020 |
Keywords
- IBD
- T cell subsets
- Vedolizumab
- alpha 4 beta 7
- chemokine receptor
- CXCL1 chemokine
- granulocyte colony stimulating factor
- heterodimer
- interleukin 17
- interleukin 7
- macrophage inflammatory protein 3beta
- tumor necrosis factor
- unclassified drug
- vedolizumab
- adult
- Article
- clinical article
- clinical outcome
- controlled study
- Crohn disease
- endoscopic biopsy
- female
- flow cytometry
- human
- human cell
- human tissue
- immunological parameters
- intervention study
- lamina propria
- lymphocyte
- male
- middle aged
- multivariate analysis
- open study
- oral biopsy
- phase 4 clinical trial
- priority journal
- prospective study
- remission
- Th1 cell
- Th17 cell
- treatment response
- ulcerative colitis
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Immunological variables associated with clinical and endoscopic response to vedolizumab in patients with inflammatory bowel diseases : Journal of Crohn's and Colitis. / Coletta, M.; Paroni, M.; Alvisi, M.F.; De Luca, M.; Rulli, E.; Mazza, S.; Facciotti, F.; Lattanzi, G.; Strati, F.; Abrignani, S.; Fantini, M.C.; Vecchi, M.; Geginat, J.; Caprioli, F.
In: J. Crohn's Colitis, Vol. 14, No. 9, 2020, p. 1190-1201.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Immunological variables associated with clinical and endoscopic response to vedolizumab in patients with inflammatory bowel diseases
T2 - Journal of Crohn's and Colitis
AU - Coletta, M.
AU - Paroni, M.
AU - Alvisi, M.F.
AU - De Luca, M.
AU - Rulli, E.
AU - Mazza, S.
AU - Facciotti, F.
AU - Lattanzi, G.
AU - Strati, F.
AU - Abrignani, S.
AU - Fantini, M.C.
AU - Vecchi, M.
AU - Geginat, J.
AU - Caprioli, F.
N1 - Cited By :1 Export Date: 2 March 2021 Correspondence Address: Caprioli, F.; Department of Pathophysiology and Transplantation, Via F. 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PY - 2020
Y1 - 2020
N2 - Background and Aims: Vedolizumab [VDZ] is a monoclonal antibody directed against the α4β7 integrin heterodimer, approved for patients with inflammatory bowel diseases [IBD]. This study aimed at identifying immunological variables associated with response to vedolizumab in patients with ulcerative colitis [UC] and Crohn's disease [CD]. Methods: This is a phase IV explorative prospective interventional trial. IBD patients received openlabel VDZ at Weeks 0, 2, 6, and 14. Patients with a clinical response at Week 14 were maintained with VDZ up to Week 54. At Weeks 0 and 14, their peripheral blood was obtained and endoscopy with biopsies was performed. The Week 14 clinical response and remission, Week 54 clinical remission, and Week 14 endoscopic response were evaluated as endpoints of the study. The expression of surface markers, chemokine receptors, and α4β7 heterodimer in peripheral blood and lamina propria lymphocytes was assessed by flow cytometry. A panel of soluble mediators was assessed in sera at baseline and at Week 14 by 45-plex. Results: A total of 38 IBD patients [20 UC, 18 CD] were included in the study. At Week 14, the clinical response and remission rates were 87% and 66%, respectively. Higher baseline levels of circulating memory Th1 cells were strongly associated with clinical response at Week 14 [p = 0.0001], whereas reduced baseline levels of lamina propria memory Th17 and Th1/17 cells were associated with endoscopic response. Immunological clusters were found to be independently associated with vedolizumab outcomes at multivariable analysis. A panel of soluble markers, including IL17A, TNF, CXCL1, CCL19 for CD and G-CSF and IL7 for UC, associated with vedolizumab-induced Week 54 clinical remission. Conclusions: The results of this exploratory study uncovered a panel of circulating and mucosal immunological variables associated with response to treatment with vedolizumab. © The Author(s) 2020.
AB - Background and Aims: Vedolizumab [VDZ] is a monoclonal antibody directed against the α4β7 integrin heterodimer, approved for patients with inflammatory bowel diseases [IBD]. This study aimed at identifying immunological variables associated with response to vedolizumab in patients with ulcerative colitis [UC] and Crohn's disease [CD]. Methods: This is a phase IV explorative prospective interventional trial. IBD patients received openlabel VDZ at Weeks 0, 2, 6, and 14. Patients with a clinical response at Week 14 were maintained with VDZ up to Week 54. At Weeks 0 and 14, their peripheral blood was obtained and endoscopy with biopsies was performed. The Week 14 clinical response and remission, Week 54 clinical remission, and Week 14 endoscopic response were evaluated as endpoints of the study. The expression of surface markers, chemokine receptors, and α4β7 heterodimer in peripheral blood and lamina propria lymphocytes was assessed by flow cytometry. A panel of soluble mediators was assessed in sera at baseline and at Week 14 by 45-plex. Results: A total of 38 IBD patients [20 UC, 18 CD] were included in the study. At Week 14, the clinical response and remission rates were 87% and 66%, respectively. Higher baseline levels of circulating memory Th1 cells were strongly associated with clinical response at Week 14 [p = 0.0001], whereas reduced baseline levels of lamina propria memory Th17 and Th1/17 cells were associated with endoscopic response. Immunological clusters were found to be independently associated with vedolizumab outcomes at multivariable analysis. A panel of soluble markers, including IL17A, TNF, CXCL1, CCL19 for CD and G-CSF and IL7 for UC, associated with vedolizumab-induced Week 54 clinical remission. Conclusions: The results of this exploratory study uncovered a panel of circulating and mucosal immunological variables associated with response to treatment with vedolizumab. © The Author(s) 2020.
KW - IBD
KW - T cell subsets
KW - Vedolizumab
KW - alpha 4 beta 7
KW - chemokine receptor
KW - CXCL1 chemokine
KW - granulocyte colony stimulating factor
KW - heterodimer
KW - interleukin 17
KW - interleukin 7
KW - macrophage inflammatory protein 3beta
KW - tumor necrosis factor
KW - unclassified drug
KW - vedolizumab
KW - adult
KW - Article
KW - clinical article
KW - clinical outcome
KW - controlled study
KW - Crohn disease
KW - endoscopic biopsy
KW - female
KW - flow cytometry
KW - human
KW - human cell
KW - human tissue
KW - immunological parameters
KW - intervention study
KW - lamina propria
KW - lymphocyte
KW - male
KW - middle aged
KW - multivariate analysis
KW - open study
KW - oral biopsy
KW - phase 4 clinical trial
KW - priority journal
KW - prospective study
KW - remission
KW - Th1 cell
KW - Th17 cell
KW - treatment response
KW - ulcerative colitis
U2 - 10.1093/ecco-jcc/jjaa035
DO - 10.1093/ecco-jcc/jjaa035
M3 - Article
VL - 14
SP - 1190
EP - 1201
JO - J. Crohn's Colitis
JF - J. Crohn's Colitis
SN - 1873-9946
IS - 9
ER -