Immunologically mediated cytotoxicity against human Eye muscle and thyroid cells in euthyroid and thyrotoxic graves' ophthalmopathy

Geraldo Medeiros-Neto; [No Value] Zhi-Guong-zhang; Nicolau Lima; Angela Iacona; Adrienne Liberman; Mario Salvi; Jack R. Wall

doi:10.3109/08916939108997131

Immunologically mediated cytotoxicity against human Eye muscle and thyroid cells in euthyroid and thyrotoxic graves' ophthalmopathy

Geraldo Medeiros-Neto, [No Value] Zhi-Guong-zhang, Nicolau Lima, Angela Iacona, Adrienne Liberman, Mario Salvi, Jack R. Wall

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

We have studied the role of eye muscle and thyroid autoimmunity in patients with Graves' hyperthyroidism with or without ophthalmopathy in an area of relatively low iodine intake. Antibody dependent cell mediated cytotoxicity (ADCC) and complement mediated antibody dependent cytotoxicity (CMAC) against thyroid and eye muscle cells, and levels of antibodies against TSH receptor antigen and the thyroid microsomal antigen (thyroid peroxidase) were determined in three groups of patients: (1) thyrotoxic with exophthalmos (TX; n= 28), (2) thyrotoxic without ophthalmopathy (GR, n= 10), and (3) euthyroid ophthalmopathy (EU, n= 12). The thyroid glandular mass of the EU group was significantly less (P

Original language	English
Pages (from-to)	293-300
Number of pages	8
Journal	Autoimmunity
Volume	9
Issue number	4
DOIs	https://doi.org/10.3109/08916939108997131
Publication status	Published - 1991

Keywords

Cytotoxicity
Eye muscle cells
Graves' disease
Iodine deficiency
Ophthalmopathy
Thyroid cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3109/08916939108997131

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Immunologically mediated cytotoxicity against human Eye muscle and thyroid cells in euthyroid and thyrotoxic graves' ophthalmopathy. / Medeiros-Neto, Geraldo; Zhi-Guong-zhang, [No Value]; Lima, Nicolau; Iacona, Angela; Liberman, Adrienne; Salvi, Mario; Wall, Jack R.

In: Autoimmunity, Vol. 9, No. 4, 1991, p. 293-300.

Research output: Contribution to journal › Article › peer-review

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AU - Medeiros-Neto, Geraldo

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AU - Lima, Nicolau

AU - Iacona, Angela

AU - Liberman, Adrienne

AU - Salvi, Mario

AU - Wall, Jack R.

PY - 1991

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KW - Graves' disease

KW - Iodine deficiency

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Immunologically mediated cytotoxicity against human Eye muscle and thyroid cells in euthyroid and thyrotoxic graves' ophthalmopathy

Abstract

Keywords

ASJC Scopus subject areas

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