Abstract
We have studied the role of eye muscle and thyroid autoimmunity in patients with Graves' hyperthyroidism with or without ophthalmopathy in an area of relatively low iodine intake. Antibody dependent cell mediated cytotoxicity (ADCC) and complement mediated antibody dependent cytotoxicity (CMAC) against thyroid and eye muscle cells, and levels of antibodies against TSH receptor antigen and the thyroid microsomal antigen (thyroid peroxidase) were determined in three groups of patients: (1) thyrotoxic with exophthalmos (TX; n= 28), (2) thyrotoxic without ophthalmopathy (GR, n= 10), and (3) euthyroid ophthalmopathy (EU, n= 12). The thyroid glandular mass of the EU group was significantly less (P
Original language | English |
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Pages (from-to) | 293-300 |
Number of pages | 8 |
Journal | Autoimmunity |
Volume | 9 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1991 |
Keywords
- Cytotoxicity
- Eye muscle cells
- Graves' disease
- Iodine deficiency
- Ophthalmopathy
- Thyroid cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology