Immunologically mediated cytotoxicity against human Eye muscle and thyroid cells in euthyroid and thyrotoxic graves' ophthalmopathy

Geraldo Medeiros-Neto, [No Value] Zhi-Guong-zhang, Nicolau Lima, Angela Iacona, Adrienne Liberman, Mario Salvi, Jack R. Wall

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the role of eye muscle and thyroid autoimmunity in patients with Graves' hyperthyroidism with or without ophthalmopathy in an area of relatively low iodine intake. Antibody dependent cell mediated cytotoxicity (ADCC) and complement mediated antibody dependent cytotoxicity (CMAC) against thyroid and eye muscle cells, and levels of antibodies against TSH receptor antigen and the thyroid microsomal antigen (thyroid peroxidase) were determined in three groups of patients: (1) thyrotoxic with exophthalmos (TX; n= 28), (2) thyrotoxic without ophthalmopathy (GR, n= 10), and (3) euthyroid ophthalmopathy (EU, n= 12). The thyroid glandular mass of the EU group was significantly less (P

Original languageEnglish
Pages (from-to)293-300
Number of pages8
JournalAutoimmunity
Volume9
Issue number4
DOIs
Publication statusPublished - 1991

Keywords

  • Cytotoxicity
  • Eye muscle cells
  • Graves' disease
  • Iodine deficiency
  • Ophthalmopathy
  • Thyroid cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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