Immunology of Alveolar and Cystic Echinococcosis (AE and CE)

B. Gottstein, P. Soboslay, E. Ortona, J. Wang, A. Siracusano, D. Vuitton

Research output: Contribution to journalArticlepeer-review

Abstract

Cystic and alveolar echinococcosis are severe chronic helminthic diseases caused by the cystic growth or the intrahepatic tumour-like growth of the metacestode of Echinococcus granulosus or Echinococcus multilocularis, respectively. Both parasites have evolved sophisticated strategies to escape host immune responses, mainly by manipulating and directing this immune response towards anergy and/or tolerance. Recent research studies have revealed a number of respective immunoregulatory mechanisms related to macrophages and dendritic cell as well as T cell activities (regulatory T cells, Tregs). A better understanding of this complex parasite–host relationship, and the elucidation of specific crucial events that lead to disease, represents targets towards the development of novel treatment strategies and options.

Original languageEnglish
Pages (from-to)1-54
Number of pages54
JournalAdvances in Parasitology
Volume96
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Alveolar echinococcosis
  • Cystic echinococcosis
  • Dendritic cells
  • Fibrinogen-like protein 2
  • Macrophages
  • Regulatory T cells
  • TGF-β
  • Vaccination

ASJC Scopus subject areas

  • Parasitology

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