Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of thyroid autoimmunity: a narrative review

D. Gallo, L. Mortara, M. B. Gariboldi, S. A.M. Cattaneo, S. Rosetti, L. Gentile, D. M. Noonan, P. Premoli, C. Cusini, M. L. Tanda, L. Bartalena, E. Piantanida

Research output: Contribution to journalReview articlepeer-review

Abstract

The main role of vitamin D is to control mineral homeostasis. However, recent studies suggested the existence of a number of extraskeletal effects. Among the latter, preclinical studies provided consistent data on the involvement of vitamin D in innate and adaptive immunity and autoimmunity. Molecular biology studies showed that both vitamin D receptor and vitamin D enzymatic complexes are expressed in a large number of cells and tissues unrelated to mineral homeostasis. In contrast, only a few randomized clinical trials in humans investigated the possible role of vitamin D in the prevention or treatment of immunological disorders. In this regard, low serum vitamin D levels have been reported in observational trials in human autoimmune disorders. The aim of the present paper was to review the potential implications of vitamin D in immune modulation, with special focus on thyroid autoimmune disorders.

Original languageEnglish
JournalJournal of Endocrinological Investigation
DOIs
Publication statusAccepted/In press - Jan 1 2019

Keywords

  • Autoimmunity
  • Graves’ diseases
  • Hashimoto’s thyroiditis
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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