Immunomodulatory effects of bovine colostrum in human peripheral blood mononuclear cells

Priscilla Biswas, Andrea Vecchi, Paola Mantegani, Barbara Mantelli, Claudio Fortis, Adriano Lazzarin

Research output: Contribution to journalArticlepeer-review


Human and bovine colostrum (BC) contain a remarkable amount of bioactive substances, including antibodies towards many common pathogens of the intestinal and respiratory tract as well as growth factors, vitamins, cytokines and other proteic, lipidic and glucidic factors. In this study we investigated whether BC had any immunomodulatory effect on human peripheral blood mononuclear cells (PBMC) from healthy donors. To this aim we focused on the production of IL-12 and IFN-γ, cytokines involved in the Th1 polarization required for a successful immune response towards intracellular pathogens, such as bacteria and viruses. BC induced a dose-dependent production of IL-12 by CD14+ monocytes, but was unable to induce IFN-γ production. However, BC differentially affected stimuli-induced IFN-γ production: it enhanced IFN-γ in response to weak antigenic stimulation and it inhibited IFN-γ in response to strong antigenic stimulation. These effects were not dose-dependent. We also measured PBMC proliferation, which was substantially unaffected by BC. Our data suggest that the Th1-promoting activity of BC could contribute, together with the antibodies, to the protective effect of BC on the offspring. BC could also represent an inexpensive therapeutic tool in prevention and treatment of several human microbial infections, including influenza.

Original languageEnglish
Pages (from-to)447-454
Number of pages8
JournalNew Microbiologica
Issue number4
Publication statusPublished - Oct 2007


  • Bovine colostrum
  • Cytokines
  • Human peripheral blood mononuclear cells
  • IfN-γ
  • IL-12
  • Immune modulation
  • Th1 response

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology


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