Immunomodulatory effects of occupational exposure to mancozeb

Claudio Colosio, Wilma Barcellini, Marco Maroni, Daniela Alcini, Maurizio Bersani, Domenico Cavallo, Andrea Galli, Pierluigi Meroni, Roberta Pastorelli, G. Paolo Rizzardi, Leonardo Soleo, Vito Foà

Research output: Contribution to journalArticlepeer-review


The effects of occupational exposure to ethylene-bis-dithiocarbamate of manganese and zinc on the immune system were evaluated in a group of mancozeb-exposed manufacturers and controls. The immune system tests revealed the following: (a) lymphocyte proliferative responses triggered by different activators and mitogen-induced IL-2 production were higher in exposed subjects than in controls; (b) production of monocyte/macrophage-derived IL- 1 and polyclonal IgG and IgM, by β-lymphocytes, did not differ between exposed subjects and controls; (c) percentages and absolute numbers of total T-cells, T-helper cells, T-suppressor/cytotoxic cells, activated T-cells, total β-cells, and natural killer cells were similar in exposed subjects and controls; (d) serum immunoglobulin classes and complement fractions were within the range of normality; and (e) rheumatoid factor and non-organ- specific serum autoantibodies were absent in exposed and control subjects. An increase in T-cell functional response was found in the exposed group, suggesting a slight immunomodulator effect of mancozeb in conditions of low- level, prolonged occupational exposure.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalArchives of Environmental Health
Issue number6
Publication statusPublished - Nov 1996

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health


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