TY - JOUR
T1 - Immunomodulatory properties of mesenchymal stem cells
T2 - A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
AU - Tyndall, Alan
AU - Walker, Ulrich A.
AU - Cope, Andrew
AU - Dazzi, Francesco
AU - De Bari, Cosimo
AU - Fibbe, Willem
AU - Guiducci, Serena
AU - Jones, Simon
AU - Jorgensen, Christian
AU - Le Blanc, Katarina
AU - Luyten, Frank
AU - McGonagle, Dennis
AU - Martin, Ivan
AU - Bocelli-Tyndall, Chiara
AU - Pennesi, Giuseppina
AU - Pistoia, Vito
AU - Pitzalis, Constantino
AU - Uccelli, Antonio
AU - Wulffraat, Nico
AU - Feldmann, Marc
PY - 2007/1/29
Y1 - 2007/1/29
N2 - Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines - an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.
AB - Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines - an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.
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U2 - 10.1186/ar2103
DO - 10.1186/ar2103
M3 - Article
AN - SCOPUS:34547907464
VL - 9
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
SN - 1478-6354
IS - 3
M1 - 301
ER -