Immunomodulatory responses to δ-opioid receptor ligands in human lymphocytes

Lia Noviello, Sergio Papadia, Maria R. Capobianchi, Lucia Negri

Research output: Contribution to journalArticlepeer-review


In phytohemagglutinin (PHA) activated human peripheral blood mononuclear cells, [3H]thymidine uptake and interferon γ production were increased by the δ-opioid receptor agonist, deltorphin-I (10-14-10-10 M) and by the δ-opioid antagonist naltrindole (10-13-10-9 M). Combination of 10-9 M naltrindole with deltorphin-I (10-12-10-8 M) significantly inhibited the proliferative response but did not affect interferon production.

Original languageEnglish
JournalEuropean Journal of Pharmacology
Issue number2
Publication statusPublished - Aug 6 1997


  • δ-Opioid receptor ligand
  • Immunomodulation
  • Lymphocyte

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology


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