In phytohemagglutinin (PHA) activated human peripheral blood mononuclear cells, [3H]thymidine uptake and interferon γ production were increased by the δ-opioid receptor agonist, deltorphin-I (10-14-10-10 M) and by the δ-opioid antagonist naltrindole (10-13-10-9 M). Combination of 10-9 M naltrindole with deltorphin-I (10-12-10-8 M) significantly inhibited the proliferative response but did not affect interferon production.
- δ-Opioid receptor ligand
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience