The pathogenetic mechanisms responsible for liver cell necrosis in viral hepatitis are still largely unknown. Several in vitro studies emphasized the importance of the host's cellular and humoral immune responses directed at virus-encoded proteins. While in HBV infection the immune response is clearly responsible of the outcome of the disease, the role of immune responses in HCV infection is still obscure and it is conceivable that this virus escapes immune surveillance through the continuous selection of mutant strains. In this article we shall discuss the most recent and significant studies on the pathogenesis of hepatocellular injury in hepatitis B and C, which are currently considered major public health problems worldwide.
|Translated title of the contribution||Immunopathogenesis of viral hepatitis|
|Number of pages||7|
|Journal||Giornale di Malattie Infettive e Parassitarie|
|Publication status||Published - 1993|
ASJC Scopus subject areas