Immunophenotype-related microRNA expression in canine chronic lymphocytic leukemia

G. Gioia, M. Mortarino, M. E. Gelain, F. Albonico, E. Ciusani, I. Forno, L. Marconato, V. Martini, S. Comazzi

Research output: Contribution to journalArticle

Abstract

MicroRNAs (miRNAs) are posttranscriptional regulatory noncoding RNAs used to profile human hematopoietic tumors. In this study, some mature miRNAs was quantitated in peripheral blood from dogs with chronic lymphocytic leukemia (CLL). Relative expression data were normalised against four endogenous controls (let-7a, miR-17-5p, miR-26b, and miR-223) selected by geNorm analysis. The results revealed distinct miRNA patterns in CLL depending on the immunophenotype. Also in dogs, the different miRNAs expression could reflect developmental lineage and tumor differentiation. The similar genetics, physiology and exposure to environment in dogs and humans make the miRNA expression study in canine CLL attractive for comparative oncology.

Original languageEnglish
Pages (from-to)228-235
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume142
Issue number3-4
DOIs
Publication statusPublished - Aug 15 2011

Keywords

  • Chronic lymphocytic leukemia
  • Dog
  • Immunophenotype
  • MicroRNA
  • Quantitative RT PCR
  • Whole blood

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Immunophenotype-related microRNA expression in canine chronic lymphocytic leukemia'. Together they form a unique fingerprint.

  • Cite this

    Gioia, G., Mortarino, M., Gelain, M. E., Albonico, F., Ciusani, E., Forno, I., Marconato, L., Martini, V., & Comazzi, S. (2011). Immunophenotype-related microRNA expression in canine chronic lymphocytic leukemia. Veterinary Immunology and Immunopathology, 142(3-4), 228-235. https://doi.org/10.1016/j.vetimm.2011.05.020