Abstract
We report the case of a patient with chronic B lymphocytic leukemia, with stable clinical and hematological conditions in the absence of any treatment. The flow cytometry analysis of the patient's cells revealed a CD19+, CD5+, IgM+, IgD+, λ chain+ phenotype, along with an unusual expression of CD8α/α homo dimer. B cells did not stain with the anti CD8β monoclonal antibody T8/2T8 5H7. Molecular biology analyses confirmed the monoclonal rearrangements of immunoglobulin heavy and λ light chain genes in the presence of a germline configuration of T cell receptor genes. Moreover, an abnormal configuration of the CD8A gene was found in the CD8+ B lymphocytic clone. We suggest that the aberrant expression of the CD8 gene could be related to its abnormal configuration.
| Original language | English |
|---|---|
| Pages (from-to) | 1544-1550 |
| Number of pages | 7 |
| Journal | Leukemia |
| Volume | 10 |
| Issue number | 9 |
| Publication status | Published - Sep 1996 |
Keywords
- B-CLL
- CD8A gene
ASJC Scopus subject areas
- Hematology
- Cancer Research