We report the case of a patient with chronic B lymphocytic leukemia, with stable clinical and hematological conditions in the absence of any treatment. The flow cytometry analysis of the patient's cells revealed a CD19+, CD5+, IgM+, IgD+, λ chain+ phenotype, along with an unusual expression of CD8α/α homo dimer. B cells did not stain with the anti CD8β monoclonal antibody T8/2T8 5H7. Molecular biology analyses confirmed the monoclonal rearrangements of immunoglobulin heavy and λ light chain genes in the presence of a germline configuration of T cell receptor genes. Moreover, an abnormal configuration of the CD8A gene was found in the CD8+ B lymphocytic clone. We suggest that the aberrant expression of the CD8 gene could be related to its abnormal configuration.
|Number of pages||7|
|Publication status||Published - Sep 1996|
- CD8A gene
ASJC Scopus subject areas
- Cancer Research