Immunoproteasome expression is induced in mesial temporal lobe epilepsy

Michele Mishto, Claudia Ligorio, Elena Bellavista, Morena Martucci, Aurelia Santoro, Marco Giulioni, Gianluca Marucci, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume408
Issue number1
DOIs
Publication statusPublished - Apr 29 2011

Keywords

  • Epilepsy surgery
  • Immunoproteasome
  • Mesial temporal lobe epilepsy
  • Neuroinflammation
  • Neuron
  • PA28
  • Proteasome

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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