Abstract
Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.
Original language | English |
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Pages (from-to) | 65-70 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 408 |
Issue number | 1 |
DOIs | |
Publication status | Published - Apr 29 2011 |
Keywords
- Epilepsy surgery
- Immunoproteasome
- Mesial temporal lobe epilepsy
- Neuroinflammation
- Neuron
- PA28
- Proteasome
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Molecular Biology