Immunoreactive calcitonin: A tumor marker for myelogenous leukemias

P. Foa, S. Ortolani, E. M. Pogliani, A. Iurlo, A. Gualdoni, A. T. Maiolo, E. E. Polli

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Abstract

In a series of 59 patients with chronic or acute myelogenous leukemia (CML, AML) we investigated whether circulating immunoreactive human calcitonin (i-hCT) levels correlate with diagnosis, response to therapy and clinical course. I-hCT was detectable in plasma samples of 88% of patients with CML in the chronic phase and in 100% of patients with CML in blastic transformation. In the AML patients, a significant relation was observed between the cytological subtype and i-hCT levels at diagnosis. In sequentially studied patients the i-hCT plasma concentration was related to the overall mass of leukemic cells, being lower when complete remission was achieved than at diagnosis and increasing at time of recurrence. These data suggest that circulating i-hCT levels can serve as a ''tumor marker'' in human myelogenous leukemias.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalInternational Journal of Biological Markers
Volume5
Issue number1
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Cite this

Foa, P., Ortolani, S., Pogliani, E. M., Iurlo, A., Gualdoni, A., Maiolo, A. T., & Polli, E. E. (1990). Immunoreactive calcitonin: A tumor marker for myelogenous leukemias. International Journal of Biological Markers, 5(1), 27-30.