Immunoregulation through extracellular nucleotides

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Extracellular ATP (eATP), the most abundant among nucleotides, can act as a mediator during inflammatory responses by binding to plasmamembrane P2 purinergic receptors, which are widely expressed on cells of the immune system. eATP is generally considered as a classical danger signal, which stimulates immune responses in the presence of tissue damage. Converging evidence from several studies using murine models of chronic inflammation have supported this hypothesis; however, the role of eATP in the regulation of human immune function appears to be more complex. Chronic stimulation with micromolar eATP concentrations inhibits the proliferation of T and NK lymphocytes and enhances the capacity of dendritic cells to promote tolerance. The effect of eATP depends on multiple factors, such as the extent of stimulation, eATP concentration, presence/absence of other mediators in the microenvironment, and pattern of P2 receptor engagement. Small but significant differences in the pattern of P2 receptor expression in mice and humans confer the diverse capacities of ATP in regulating the immune response. Such diversity, which is often overlooked, should therefore be carefully considered when evaluating the role of eATP in human inflammatory and autoimmune diseases.

Original languageEnglish
Pages (from-to)511-518
Number of pages8
JournalBlood
Volume120
Issue number3
DOIs
Publication statusPublished - Jul 19 2012

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Nucleotides
Adenosine Triphosphate
Purinergic P2 Receptors
Lymphocytes
Immune system
Dendritic Cells
Autoimmune Diseases
Immune System
Tissue
Inflammation

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Immunoregulation through extracellular nucleotides. / Vitiello, Laura; Gorini, Stefania; Rosano, Giuseppe; La Sala, Andrea.

In: Blood, Vol. 120, No. 3, 19.07.2012, p. 511-518.

Research output: Contribution to journalArticle

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