Immunoregulatory cytokine polymorphisms in Italian patients affected by paroxysmal nocturnal haemoglobinuria and aplastic anaemia

E. Fermo, P. Bianchi, W. Barcellini, P. Pedotti, C. Boschetti, F. Alfinito, A. Cortelezzi, Alberto Zanella

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated regulatory variants of five cytokine genes [tumour necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, interleukin (IL)-6 and IL-10] in 40 Italian patients affected by paroxysmal nocturnal haemoglobinuria (PNH) and aplastic anaemia (AA). Genotypes associated with high production of TGF-β and IFN-γ were more frequent in patients than in controls. Genetic regulation of the immunological pathways involved in the pathogenesis of bone marrow failure is suggested.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalEuropean Journal of Immunogenetics
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 2004

ASJC Scopus subject areas

  • Genetics
  • Immunology

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