Immunoregulatory cytokine polymorphisms in Italian patients affected by paroxysmal nocturnal haemoglobinuria and aplastic anaemia

E. Fermo, P. Bianchi, W. Barcellini, P. Pedotti, C. Boschetti, F. Alfinito, A. Cortelezzi, Alberto Zanella

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Abstract

We investigated regulatory variants of five cytokine genes [tumour necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, interleukin (IL)-6 and IL-10] in 40 Italian patients affected by paroxysmal nocturnal haemoglobinuria (PNH) and aplastic anaemia (AA). Genotypes associated with high production of TGF-β and IFN-γ were more frequent in patients than in controls. Genetic regulation of the immunological pathways involved in the pathogenesis of bone marrow failure is suggested.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalEuropean Journal of Immunogenetics
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 2004

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Paroxysmal Hemoglobinuria
Aplastic Anemia
Transforming Growth Factors
Interferons
Cytokines
Interleukin-10
Interleukin-6
Tumor Necrosis Factor-alpha
Bone Marrow
Genotype
Genes

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

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AU - Fermo, E.

AU - Bianchi, P.

AU - Barcellini, W.

AU - Pedotti, P.

AU - Boschetti, C.

AU - Alfinito, F.

AU - Cortelezzi, A.

AU - Zanella, Alberto

PY - 2004/12

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