Immunoregulatory function of mesenchymal stem cells

Antonio Uccelli, Lorenzo Moretta, Vito Pistoia

Research output: Contribution to journalArticle

Abstract

Mesenchymal stem cells (MSC) are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. MSC can differentiate into multiple mesenchymal and non-mesenchymal lineages, providing a promising tool for tissue repair. In addition, MSC suppress many T cell, B cell and NK cell functions and may affect also dendritic cell activities. Due to their limited immunogenicity, MSC are poorly recognized by HLA-incompatible hosts. Based on these unique properties, MSC are currently under inivestigation for their possible use to treat immuno-mediated diseases. However, both their condition of immunoprivilege and their immunosuppressive function have recently been challenged when analyzed under particular experimental conditions. Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell-to-cell interactions, but also by environmental factors shaping their phenotype and functions.

Original languageEnglish
Pages (from-to)2566-2573
Number of pages8
JournalEuropean Journal of Immunology
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 2006

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Keywords

  • B cells
  • Dendritic cells
  • Mesenchymal stem cells
  • NK cells
  • T cells

ASJC Scopus subject areas

  • Immunology

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