Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Francesco Puppo; Massimo Ghio; Paola Contini; Sabrina Brenci; Donatella Bignardi; Gilberto Filaci; Marco Scudeletti; Francesco Indiveri

Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Francesco Puppo, Massimo Ghio, Paola Contini, Sabrina Brenci, Donatella Bignardi, Gilberto Filaci, Marco Scudeletti, Francesco Indiveri

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume	46
Issue number	3
Publication status	Published - 1998

Keywords

Graft recipients
Graft rejections
Hla soluble molecules

ASJC Scopus subject areas

Immunology

Cite this

Immunoregulatory Role of Soluble HLA Molecules : A New Skin for an Old Subject? / Puppo, Francesco; Ghio, Massimo; Contini, Paola; Brenci, Sabrina; Bignardi, Donatella; Filaci, Gilberto; Scudeletti, Marco; Indiveri, Francesco.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 46, No. 3, 1998, p. 157-160.

Research output: Contribution to journal › Article › peer-review

@article{ba7c0be9456b464eb2a49f75c3d4b28a,

title = "Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?",

abstract = "The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.",

keywords = "Graft recipients, Graft rejections, Hla soluble molecules",

author = "Francesco Puppo and Massimo Ghio and Paola Contini and Sabrina Brenci and Donatella Bignardi and Gilberto Filaci and Marco Scudeletti and Francesco Indiveri",

year = "1998",

language = "English",

volume = "46",

pages = "157--160",

journal = "Archivum Immunologiae et Therapiae Experimentalis",

issn = "0004-069X",

publisher = "Birkhauser Verlag Basel",

number = "3",

}

TY - JOUR

T1 - Immunoregulatory Role of Soluble HLA Molecules

T2 - A New Skin for an Old Subject?

AU - Puppo, Francesco

AU - Ghio, Massimo

AU - Contini, Paola

AU - Brenci, Sabrina

AU - Bignardi, Donatella

AU - Filaci, Gilberto

AU - Scudeletti, Marco

AU - Indiveri, Francesco

PY - 1998

Y1 - 1998

N2 - The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

AB - The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

KW - Graft recipients

KW - Graft rejections

KW - Hla soluble molecules

UR - http://www.scopus.com/inward/record.url?scp=0031609949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031609949&partnerID=8YFLogxK

M3 - Article

C2 - 9704147

AN - SCOPUS:0031609949

VL - 46

SP - 157

EP - 160

JO - Archivum Immunologiae et Therapiae Experimentalis

JF - Archivum Immunologiae et Therapiae Experimentalis

SN - 0004-069X

IS - 3

ER -

Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this