Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Francesco Puppo, Massimo Ghio, Paola Contini, Sabrina Brenci, Donatella Bignardi, Gilberto Filaci, Marco Scudeletti, Francesco Indiveri

Research output: Contribution to journalArticlepeer-review


The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalArchivum Immunologiae et Therapiae Experimentalis
Issue number3
Publication statusPublished - 1998


  • Graft recipients
  • Graft rejections
  • Hla soluble molecules

ASJC Scopus subject areas

  • Immunology


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