Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Francesco Puppo; Massimo Ghio; Paola Contini; Sabrina Brenci; Donatella Bignardi; Gilberto Filaci; Marco Scudeletti; Francesco Indiveri

Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Francesco Puppo, Massimo Ghio, Paola Contini, Sabrina Brenci, Donatella Bignardi, Gilberto Filaci, Marco Scudeletti, Francesco Indiveri

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume	46
Issue number	3
Publication status	Published - 1998

Keywords

Graft recipients
Graft rejections
Hla soluble molecules

ASJC Scopus subject areas

Immunology

Cite this

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title = "Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?",

abstract = "The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.",

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AU - Puppo, Francesco

AU - Ghio, Massimo

AU - Contini, Paola

AU - Brenci, Sabrina

AU - Bignardi, Donatella

AU - Filaci, Gilberto

AU - Scudeletti, Marco

AU - Indiveri, Francesco

PY - 1998

Y1 - 1998

N2 - The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

AB - The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

KW - Graft recipients

KW - Graft rejections

KW - Hla soluble molecules

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Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Abstract

Keywords

ASJC Scopus subject areas

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