Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Francesco Puppo; Massimo Ghio; Paola Contini; Sabrina Brenci; Donatella Bignardi; Gilberto Filaci; Marco Scudeletti; Francesco Indiveri

Immunoregulatory Role of Soluble HLA Molecules: A New Skin for an Old Subject?

Francesco Puppo, Massimo Ghio, Paola Contini, Sabrina Brenci, Donatella Bignardi, Gilberto Filaci, Marco Scudeletti, Francesco Indiveri

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The available evidence suggests that measurement of the level of total sHLA-1 antigens and of donor-derived and recipient-derived allospecificities as well as the characterization of their variants in recipient's serum may provide useful information to differentiate graft rejections from infections in allograft recipients. Moreover, a significant progress has been made in our understanding of the functional properties of sHLA-I antigens in serum and of their potential role in the modulation of immune responses. If these preliminary results will be confirmed, then sHLA-I antigens are likely to become important reagents to monitor and treat graft recipients.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume	46
Issue number	3
Publication status	Published - 1998

Keywords

Graft recipients
Graft rejections
Hla soluble molecules

ASJC Scopus subject areas

Immunology

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Immunoregulatory Role of Soluble HLA Molecules : A New Skin for an Old Subject? / Puppo, Francesco; Ghio, Massimo; Contini, Paola; Brenci, Sabrina; Bignardi, Donatella; Filaci, Gilberto; Scudeletti, Marco; Indiveri, Francesco.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 46, No. 3, 1998, p. 157-160.

Research output: Contribution to journal › Article › peer-review

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AU - Scudeletti, Marco

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