Immunoregulatory subpopulations of human T lymphocytes

L. Moretta, M. C. Mingari, A. Moretta, C. A. Romanzi

Research output: Contribution to journalArticlepeer-review


Human T lymphocyte subpopulations can be identified on the basis of surface receptors for G or M immunoglobulins [T(M) and T(G) cells respectively]. Isolated T(M) or T(G) cells can be analyzed in vitro for their morphology and their functional properties. In addition to unique characteristics observed in light and electron microscopy. T(M) and T(G) cells show a different pattern of responsiveness to PHA and alloantigens. The major functional difference so far observed concerns their interaction with B lymphocytes. T(M) cells provide help for the T-dependent responses of B lymphocytes to pokeweed mitogen (PWM), whereas T(G) cells suppress B lymphocyte activation in this in vitro system by inhibiting helper T(M) cells. Imbalances and/or functional alterations of T(M) and T(G) cells are present in various immunological disorders and are possibly involved in the pathogenesis of these diseases.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
Issue number1
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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