Immunoregulatory subpopulations of human T lymphocytes

L. Moretta, M. C. Mingari, A. Moretta, C. A. Romanzi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Human T lymphocyte subpopulations can be identified on the basis of surface receptors for G or M immunoglobulins [T(M) and T(G) cells respectively]. Isolated T(M) or T(G) cells can be analyzed in vitro for their morphology and their functional properties. In addition to unique characteristics observed in light and electron microscopy. T(M) and T(G) cells show a different pattern of responsiveness to PHA and alloantigens. The major functional difference so far observed concerns their interaction with B lymphocytes. T(M) cells provide help for the T-dependent responses of B lymphocytes to pokeweed mitogen (PWM), whereas T(G) cells suppress B lymphocyte activation in this in vitro system by inhibiting helper T(M) cells. Imbalances and/or functional alterations of T(M) and T(G) cells are present in various immunological disorders and are possibly involved in the pathogenesis of these diseases.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
JournalBiomedicine
Volume30
Issue number1
Publication statusPublished - 1979

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Gastrin-Secreting Cells
T-cells
Lymphocytes
T-Lymphocytes
B-Lymphocytes
IgG Receptors
Pokeweed Mitogens
Isoantigens
Electron microscopy
Optical microscopy
Chemical activation
Lymphocyte Subsets
Lymphocyte Activation
Helper-Inducer T-Lymphocytes
Immunoglobulin M
Electron Microscopy
Light

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Immunoregulatory subpopulations of human T lymphocytes. / Moretta, L.; Mingari, M. C.; Moretta, A.; Romanzi, C. A.

In: Biomedicine, Vol. 30, No. 1, 1979, p. 4-8.

Research output: Contribution to journalArticle

Moretta, L, Mingari, MC, Moretta, A & Romanzi, CA 1979, 'Immunoregulatory subpopulations of human T lymphocytes', Biomedicine, vol. 30, no. 1, pp. 4-8.
Moretta, L. ; Mingari, M. C. ; Moretta, A. ; Romanzi, C. A. / Immunoregulatory subpopulations of human T lymphocytes. In: Biomedicine. 1979 ; Vol. 30, No. 1. pp. 4-8.
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