Abstract
Human T lymphocyte subpopulations can be identified on the basis of surface receptors for G or M immunoglobulins [T(M) and T(G) cells respectively]. Isolated T(M) or T(G) cells can be analyzed in vitro for their morphology and their functional properties. In addition to unique characteristics observed in light and electron microscopy. T(M) and T(G) cells show a different pattern of responsiveness to PHA and alloantigens. The major functional difference so far observed concerns their interaction with B lymphocytes. T(M) cells provide help for the T-dependent responses of B lymphocytes to pokeweed mitogen (PWM), whereas T(G) cells suppress B lymphocyte activation in this in vitro system by inhibiting helper T(M) cells. Imbalances and/or functional alterations of T(M) and T(G) cells are present in various immunological disorders and are possibly involved in the pathogenesis of these diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 4-8 |
| Number of pages | 5 |
| Journal | Biomedicine |
| Volume | 30 |
| Issue number | 1 |
| Publication status | Published - 1979 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Immunoregulatory subpopulations of human T lymphocytes. / Moretta, L.; Mingari, M. C.; Moretta, A.; Romanzi, C. A.
In: Biomedicine, Vol. 30, No. 1, 1979, p. 4-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunoregulatory subpopulations of human T lymphocytes
AU - Moretta, L.
AU - Mingari, M. C.
AU - Moretta, A.
AU - Romanzi, C. A.
PY - 1979
Y1 - 1979
N2 - Human T lymphocyte subpopulations can be identified on the basis of surface receptors for G or M immunoglobulins [T(M) and T(G) cells respectively]. Isolated T(M) or T(G) cells can be analyzed in vitro for their morphology and their functional properties. In addition to unique characteristics observed in light and electron microscopy. T(M) and T(G) cells show a different pattern of responsiveness to PHA and alloantigens. The major functional difference so far observed concerns their interaction with B lymphocytes. T(M) cells provide help for the T-dependent responses of B lymphocytes to pokeweed mitogen (PWM), whereas T(G) cells suppress B lymphocyte activation in this in vitro system by inhibiting helper T(M) cells. Imbalances and/or functional alterations of T(M) and T(G) cells are present in various immunological disorders and are possibly involved in the pathogenesis of these diseases.
AB - Human T lymphocyte subpopulations can be identified on the basis of surface receptors for G or M immunoglobulins [T(M) and T(G) cells respectively]. Isolated T(M) or T(G) cells can be analyzed in vitro for their morphology and their functional properties. In addition to unique characteristics observed in light and electron microscopy. T(M) and T(G) cells show a different pattern of responsiveness to PHA and alloantigens. The major functional difference so far observed concerns their interaction with B lymphocytes. T(M) cells provide help for the T-dependent responses of B lymphocytes to pokeweed mitogen (PWM), whereas T(G) cells suppress B lymphocyte activation in this in vitro system by inhibiting helper T(M) cells. Imbalances and/or functional alterations of T(M) and T(G) cells are present in various immunological disorders and are possibly involved in the pathogenesis of these diseases.
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M3 - Article
C2 - 313817
AN - SCOPUS:0018769364
VL - 30
SP - 4
EP - 8
JO - Biomedicine
JF - Biomedicine
SN - 0970-2067
IS - 1
ER -