Immunoscintigraphy in the follow-up of patients operated on for carcinoma of the sigmoid and rectum - Preliminary report with a new monoclonal antibody: B72.3

A. Renda, M. Salvatore, M. Sava, R. Landi, S. Lastoria, L. Coppola, J. Schlom, D. Colcher, G. Zannini

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Thirty patients who had curative surgery for sigmoid and rectal carcinoma were studied by immunoscintigraphy using a new monoclonal antibody: B72.3 radiolabeled with Iodine-131 (I-131) or Indium-111 (In-111). Results were compared with other conventional diagnostic procedures such as computed tomography, ultrasound, endoscopy, and tumor markers. Seven patients had local recurrences and/or distant metastases. Immunoscintigraphy identified all local recurrences (five cases) that were confirmed by CT and was able to localize three of five liver metastases (two false-negatives). Furthermore, immunoscintigraphy also recorded a false-positive. Preliminary use of B72.3 shows good potential for the evaluation and detection of neoplastic sites.

Original languageEnglish
Pages (from-to)683-686
Number of pages4
JournalDiseases of the Colon and Rectum
Volume30
Issue number9
DOIs
Publication statusPublished - Sep 1987

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Sigmoid Colon
Rectum
Monoclonal Antibodies
Neoplasm Metastasis
Carcinoma
Recurrence
Indium
Tumor Biomarkers
Iodine
Endoscopy
Tomography
Liver
B72.3 antibody

Keywords

  • Immunoscintigraphy
  • Monoclonal antibody
  • Rectal cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Immunoscintigraphy in the follow-up of patients operated on for carcinoma of the sigmoid and rectum - Preliminary report with a new monoclonal antibody : B72.3. / Renda, A.; Salvatore, M.; Sava, M.; Landi, R.; Lastoria, S.; Coppola, L.; Schlom, J.; Colcher, D.; Zannini, G.

In: Diseases of the Colon and Rectum, Vol. 30, No. 9, 09.1987, p. 683-686.

Research output: Contribution to journalArticle

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