Immunoscintigraphy in the follow-up of patients operated on for carcinoma of the sigmoid and rectum - Preliminary report with a new monoclonal antibody: B72.3

A. Renda, M. Salvatore, M. Sava, R. Landi, S. Lastoria, L. Coppola, J. Schlom, D. Colcher, G. Zannini

Research output: Contribution to journalArticle

Abstract

Thirty patients who had curative surgery for sigmoid and rectal carcinoma were studied by immunoscintigraphy using a new monoclonal antibody: B72.3 radiolabeled with Iodine-131 (I-131) or Indium-111 (In-111). Results were compared with other conventional diagnostic procedures such as computed tomography, ultrasound, endoscopy, and tumor markers. Seven patients had local recurrences and/or distant metastases. Immunoscintigraphy identified all local recurrences (five cases) that were confirmed by CT and was able to localize three of five liver metastases (two false-negatives). Furthermore, immunoscintigraphy also recorded a false-positive. Preliminary use of B72.3 shows good potential for the evaluation and detection of neoplastic sites.

Original languageEnglish
Pages (from-to)683-686
Number of pages4
JournalDiseases of the Colon and Rectum
Volume30
Issue number9
DOIs
Publication statusPublished - Sep 1987

Keywords

  • Immunoscintigraphy
  • Monoclonal antibody
  • Rectal cancer

ASJC Scopus subject areas

  • Gastroenterology

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