Immunoscintigraphy of melanoma using radiolabelled antibodies: Pilot, prospective studies and Italian multicenter clinical trials

G. L. Buraggi, M. Gasparini

Research output: Contribution to journalArticlepeer-review

Abstract

The studies on radioimmunodetection of malignant melanoma reported are based on the use of the 225.28S monoclonal antibody against a high molecular weight melanoma associated antigen, an IgG2a isolated and characterized by Ferrone et al. The strategy followed by us to check the characteristics and the behaviour of this antibody and to verify its possible use in clinical praxis, includes three groups of trials performed from 1982 to 1987. A pilot study was performed on 42 patients with 74 melanoma lesions, a multicenter study was realized, with the collaboration of 10 Italian nuclear medicine centers, on 254 patients with 539 lesions and prospective study performed on 44 patients with 54 suspected regional lymph nodes involvements. High sensitivity and specificity were obtained especially with the use of technetium compound which also allowed the attainment of very high predictive values of positive tests. No adverse reactions were noticed.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalNuclear Medicine and Biology
Volume16
Issue number6
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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