Immunoscintigraphy with a technetium-99m labelled anti-epithelial growth factor receptor antibody in patients with non-small cell lung cancer

Orazio Schillaci, Roberta Danieli, Valentina Picardi, Oreste Bagni, Mario Di Loreto, Francesco Scopinaro

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A variety of human tumours, including non-small cell lung cancer, overexpress epithelial growth factor (EGF) receptors. In this study we evaluated the feasibility of immunoscintigraphy with a technetium-99m-labelled monoclonal antibody directed towards the EGF receptor (MINT5). Materials and Methods: The labelling with technetium-99m was performed using the glucoheptonate-iminothiolane method. Eight patients with non-small cell lung cancer were i.v. injected 740 MBq of MINT5. Neither side-effects, nor toxicity, nor HAMA response were observed. Each patient was submitted to total body planar images in anterior and posterior projections at 1-2 hours and at 4-6 hours after the injection. Results: Uptake of MINT5 was mainly visible in liver, spleen and bone marrow; it proved stable in vivo. The primary lung cancer was imaged in 7 out of 8 patients and metastases were detected in 3 out of 3 cases. Conclusion:. MINT5 is a safe and promising radiopharmaceutical for in vivo localization and biological characterization of non-small cell lung cancer.

Original languageEnglish
Pages (from-to)3571-3574
Number of pages4
JournalAnticancer Research
Volume21
Issue number5
Publication statusPublished - 2001

Keywords

  • Epithelial growth factor receptor
  • Immunoscintigraphy
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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