Abstract
Synergism between chemotherapy and immune responses has been evidenced in animals and man. In addition, non-specific immunostimulation seems to increase the efficiency of anticancer chemotherapy. Up to now most of the clinical trials have been conducted applying immunoadjuvants after initial chemotherapeutic treatment. Since presensitized immunocompetent cells are more radio- and chemo-resistant than non-stimulated lymphocytes, a trial of immunostimulation before chemotherapy is based on rational experimental basis. Such program, activated in humans during 1976, is conducted according to the following general scheme:o1.Chemotherapy alone2.Chemotherapy followed by BCG and recycle3.Chemotherapy preceded and followed by BCG and recycle. Protocols for breast, lung, colorectal and ovarian cancer treatment are described.
| Original language | English |
|---|---|
| Pages (from-to) | 689-699 |
| Number of pages | 11 |
| Journal | Pharmacological Research Communications |
| Volume | 9 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1977 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Immunostimulation before chemotherapy in cancer treatment. / Frati, L.; Barzi, A.; Caprino, M. C.; Menconi, E.; Bonmassar, E.
In: Pharmacological Research Communications, Vol. 9, No. 8, 1977, p. 689-699.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunostimulation before chemotherapy in cancer treatment
AU - Frati, L.
AU - Barzi, A.
AU - Caprino, M. C.
AU - Menconi, E.
AU - Bonmassar, E.
PY - 1977
Y1 - 1977
N2 - Synergism between chemotherapy and immune responses has been evidenced in animals and man. In addition, non-specific immunostimulation seems to increase the efficiency of anticancer chemotherapy. Up to now most of the clinical trials have been conducted applying immunoadjuvants after initial chemotherapeutic treatment. Since presensitized immunocompetent cells are more radio- and chemo-resistant than non-stimulated lymphocytes, a trial of immunostimulation before chemotherapy is based on rational experimental basis. Such program, activated in humans during 1976, is conducted according to the following general scheme:o1.Chemotherapy alone2.Chemotherapy followed by BCG and recycle3.Chemotherapy preceded and followed by BCG and recycle. Protocols for breast, lung, colorectal and ovarian cancer treatment are described.
AB - Synergism between chemotherapy and immune responses has been evidenced in animals and man. In addition, non-specific immunostimulation seems to increase the efficiency of anticancer chemotherapy. Up to now most of the clinical trials have been conducted applying immunoadjuvants after initial chemotherapeutic treatment. Since presensitized immunocompetent cells are more radio- and chemo-resistant than non-stimulated lymphocytes, a trial of immunostimulation before chemotherapy is based on rational experimental basis. Such program, activated in humans during 1976, is conducted according to the following general scheme:o1.Chemotherapy alone2.Chemotherapy followed by BCG and recycle3.Chemotherapy preceded and followed by BCG and recycle. Protocols for breast, lung, colorectal and ovarian cancer treatment are described.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017642124&partnerID=8YFLogxK
U2 - 10.1016/S0031-6989(77)80060-X
DO - 10.1016/S0031-6989(77)80060-X
M3 - Article
C2 - 563086
AN - SCOPUS:0017642124
VL - 9
SP - 689
EP - 699
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 8
ER -