Abstract
Background: Multifocal motor neuropathy is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partialmotor nerve conduction blocks. Intravenous immunoglobulin is beneficial but the role of immunosuppressive agents is uncertain. Objectives: To provide the best available evidence from randomised controlled trials on the role of immunosuppressive agents for the treatment of multifocal motor neuropathy. Search strategy: For this update, we searched the Cochrane Neuromuscular Disease Group Trials Register (October 8 2008), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 4), MEDLINE (from January 1966 to October 8 2008), and EMBASE (from January 1980 to October 8 2008), for trials of multifocal motor neuropathy. Selection criteria: Randomised and quasi-randomised controlled trials were to be included and one was found. Prospective and retrospective case series and case reports were considered in the Discussion. Data collection and analysis: Two review authors searched the titles and abstracts of the articles identified and extracted the data independently. Main results: In this update, we found the first randomised controlled trial of multifocal motor neuropathy. This study, which randomised 28 patients, showed that mycophenolate mofetil did not significantly improve strength or function or reduce the need for intravenous immunoglobulin. We summarised the results of retrospective and prospective case series in the discussion. Authors' conclusions: In the only randomised placebo-controlled trial of any immunosuppressive agent, mycophenolate mofetil did not produce significant benefit. Trials of other immunosuppressants should be undertaken.
| Original language | English |
|---|---|
| Article number | CD003217 |
| Journal | The Cochrane database of systematic reviews |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 |
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ASJC Scopus subject areas
- Medicine(all)
- Pharmacology (medical)
Cite this
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. / Umapathi, T.; Hughes, Richard A C; Nobile-Orazio, Eduardo; Léger, Jean Marc.
In: The Cochrane database of systematic reviews, No. 1, CD003217, 2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy
AU - Umapathi, T.
AU - Hughes, Richard A C
AU - Nobile-Orazio, Eduardo
AU - Léger, Jean Marc
PY - 2009
Y1 - 2009
N2 - Background: Multifocal motor neuropathy is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partialmotor nerve conduction blocks. Intravenous immunoglobulin is beneficial but the role of immunosuppressive agents is uncertain. Objectives: To provide the best available evidence from randomised controlled trials on the role of immunosuppressive agents for the treatment of multifocal motor neuropathy. Search strategy: For this update, we searched the Cochrane Neuromuscular Disease Group Trials Register (October 8 2008), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 4), MEDLINE (from January 1966 to October 8 2008), and EMBASE (from January 1980 to October 8 2008), for trials of multifocal motor neuropathy. Selection criteria: Randomised and quasi-randomised controlled trials were to be included and one was found. Prospective and retrospective case series and case reports were considered in the Discussion. Data collection and analysis: Two review authors searched the titles and abstracts of the articles identified and extracted the data independently. Main results: In this update, we found the first randomised controlled trial of multifocal motor neuropathy. This study, which randomised 28 patients, showed that mycophenolate mofetil did not significantly improve strength or function or reduce the need for intravenous immunoglobulin. We summarised the results of retrospective and prospective case series in the discussion. Authors' conclusions: In the only randomised placebo-controlled trial of any immunosuppressive agent, mycophenolate mofetil did not produce significant benefit. Trials of other immunosuppressants should be undertaken.
AB - Background: Multifocal motor neuropathy is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partialmotor nerve conduction blocks. Intravenous immunoglobulin is beneficial but the role of immunosuppressive agents is uncertain. Objectives: To provide the best available evidence from randomised controlled trials on the role of immunosuppressive agents for the treatment of multifocal motor neuropathy. Search strategy: For this update, we searched the Cochrane Neuromuscular Disease Group Trials Register (October 8 2008), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 4), MEDLINE (from January 1966 to October 8 2008), and EMBASE (from January 1980 to October 8 2008), for trials of multifocal motor neuropathy. Selection criteria: Randomised and quasi-randomised controlled trials were to be included and one was found. Prospective and retrospective case series and case reports were considered in the Discussion. Data collection and analysis: Two review authors searched the titles and abstracts of the articles identified and extracted the data independently. Main results: In this update, we found the first randomised controlled trial of multifocal motor neuropathy. This study, which randomised 28 patients, showed that mycophenolate mofetil did not significantly improve strength or function or reduce the need for intravenous immunoglobulin. We summarised the results of retrospective and prospective case series in the discussion. Authors' conclusions: In the only randomised placebo-controlled trial of any immunosuppressive agent, mycophenolate mofetil did not produce significant benefit. Trials of other immunosuppressants should be undertaken.
UR - http://www.scopus.com/inward/record.url?scp=70249128280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70249128280&partnerID=8YFLogxK
U2 - 10.1002/14651858.CD003217.pub3
DO - 10.1002/14651858.CD003217.pub3
M3 - Article
JO - Cochrane Database of Systematic Reviews
JF - Cochrane Database of Systematic Reviews
SN - 1361-6137
IS - 1
M1 - CD003217
ER -