Abstract
The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.
Original language | English |
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Pages (from-to) | 13-17 |
Number of pages | 5 |
Journal | Oncology |
Volume | 48 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1991 |
Keywords
- CA 125
- Immunosuppresive acidic protein
- Ovarian cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology