Immunosuppressive acidic protein and CA 125 levels in patients with ovarian cancer

Mauro Castelli; F. Battaglia; G. Scambia; P. Benedetti Panici; G. Ferrandina; A. M. Mileo; S. Mancuso; U. Ferrini

doi:10.1159/000226886

Immunosuppressive acidic protein and CA 125 levels in patients with ovarian cancer

Mauro Castelli, F. Battaglia, G. Scambia, P. Benedetti Panici, G. Ferrandina, A. M. Mileo, S. Mancuso, U. Ferrini

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Oncology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1159/000226886
Publication status	Published - 1991

Keywords

CA 125
Immunosuppresive acidic protein
Ovarian cancer

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1159/000226886

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title = "Immunosuppressive acidic protein and CA 125 levels in patients with ovarian cancer",

abstract = "The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.",

keywords = "CA 125, Immunosuppresive acidic protein, Ovarian cancer",

author = "Mauro Castelli and F. Battaglia and G. Scambia and {Benedetti Panici}, P. and G. Ferrandina and Mileo, {A. M.} and S. Mancuso and U. Ferrini",

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AU - Castelli, Mauro

AU - Battaglia, F.

AU - Scambia, G.

AU - Benedetti Panici, P.

AU - Ferrandina, G.

AU - Mileo, A. M.

AU - Mancuso, S.

AU - Ferrini, U.

PY - 1991

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N2 - The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.

AB - The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.

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