Abstract
The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.
| Original language | English |
|---|---|
| Pages (from-to) | 13-17 |
| Number of pages | 5 |
| Journal | Oncology |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- CA 125
- Immunosuppresive acidic protein
- Ovarian cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Immunosuppressive acidic protein and CA 125 levels in patients with ovarian cancer. / Castelli, Mauro; Battaglia, F.; Scambia, G.; Benedetti Panici, P.; Ferrandina, G.; Mileo, A. M.; Mancuso, S.; Ferrini, U.
In: Oncology, Vol. 48, No. 1, 1991, p. 13-17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunosuppressive acidic protein and CA 125 levels in patients with ovarian cancer
AU - Castelli, Mauro
AU - Battaglia, F.
AU - Scambia, G.
AU - Benedetti Panici, P.
AU - Ferrandina, G.
AU - Mileo, A. M.
AU - Mancuso, S.
AU - Ferrini, U.
PY - 1991
Y1 - 1991
N2 - The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.
AB - The serum levels of immunosuppressive acid protein (IAP) and CA 125 were determined in 98 patients with ovarian cancer, in 20 patients with benign ovarian tumors and in a group of normal postmenopausal women as controls. On the basis of the mean values of normal controls (346.46±133.26 µg/ml), the IAP threshold was fixed at 613 µg/ml. Increased IAP levels were found in 70.4% of patients with ovarian cancer, in 25% of benign tumors and in 4.5% of normal women. Elevated levels of CA 125 were observed in 66.6% of cancers, in 40% of benign tumors and in 6.9% of controls. In particular, in early stage ovarian cancer the combined assay of the two markers increased by about 30% with respect to CA 125 alone. The simultaneous determination of IAP and CA 125 allowed an overall sensitivity of 84% without any significant reduction of specificity.
KW - CA 125
KW - Immunosuppresive acidic protein
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=0026057077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026057077&partnerID=8YFLogxK
U2 - 10.1159/000226886
DO - 10.1159/000226886
M3 - Article
C2 - 1987493
AN - SCOPUS:0026057077
VL - 48
SP - 13
EP - 17
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 1
ER -