TY - JOUR
T1 - Terapia immunosoppressiva in boli (pulse therapy) nel pemfigo
AU - Montesu, M. A.
AU - De Simone, C.
AU - Masala, M. V.
AU - Diociaiuti, A.
AU - Cottoni, F.
AU - Cerimele, D.
PY - 2000
Y1 - 2000
N2 - Background. Pemphigus vulgaris (PV) had high mortality rates in the past but, thanks to the introduction of cortisone-based therapies, these have lowered considerably. However, prolonged use of these drugs leads to many undesirable side-effects, this is why therapies are associated with immunosuppressing agents. Methods. The present study used pulse therapy with methylprednisolone and cyclophosphamide at high doses in 17 patients. Thirteen cases had PV, 2 had pemphigus foliaceus (PF) and 2 had pemphigus seborrhoic (PS). Twelve patients were males and 5 females, with ages ranging from 24 to 73 years. Each patient underwent hematochemical tests, X-ray and scans designed to show possible pathologies for which this type of therapy is contraindicated. The patients underwent a variable number of cycles from 6 to 18. In 7 patients, from the onset of therapy and at every successive cycle, samples were tested for circulating antibodies. Follow-up on pemphigus patients treated in this way varied between a few months and 2 years. Results. Fourteen patients showed considerable improvement in clinical picture, and 2 patients with PF and 1 with PV showed no improvement. Evaluation of circulating antibodies resulted slightly lowered, but only 2 cases became negative. Conclusions. The good response to therapy showed in this study leads us to propose the above mentioned protocol, where possible, as an excellent alternative to continued, prolonged and exclusive use of cortisone-based therapy.
AB - Background. Pemphigus vulgaris (PV) had high mortality rates in the past but, thanks to the introduction of cortisone-based therapies, these have lowered considerably. However, prolonged use of these drugs leads to many undesirable side-effects, this is why therapies are associated with immunosuppressing agents. Methods. The present study used pulse therapy with methylprednisolone and cyclophosphamide at high doses in 17 patients. Thirteen cases had PV, 2 had pemphigus foliaceus (PF) and 2 had pemphigus seborrhoic (PS). Twelve patients were males and 5 females, with ages ranging from 24 to 73 years. Each patient underwent hematochemical tests, X-ray and scans designed to show possible pathologies for which this type of therapy is contraindicated. The patients underwent a variable number of cycles from 6 to 18. In 7 patients, from the onset of therapy and at every successive cycle, samples were tested for circulating antibodies. Follow-up on pemphigus patients treated in this way varied between a few months and 2 years. Results. Fourteen patients showed considerable improvement in clinical picture, and 2 patients with PF and 1 with PV showed no improvement. Evaluation of circulating antibodies resulted slightly lowered, but only 2 cases became negative. Conclusions. The good response to therapy showed in this study leads us to propose the above mentioned protocol, where possible, as an excellent alternative to continued, prolonged and exclusive use of cortisone-based therapy.
KW - Anti-inflammatory agents
KW - Cyclophosphamide administration and dosage
KW - Immunosuppressive agents administration and dosage
KW - Pemphigus
KW - Steroidal therapeutic use
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M3 - Articolo
AN - SCOPUS:0034459561
VL - 135
SP - 665
EP - 668
JO - Minerva dermatologica
JF - Minerva dermatologica
SN - 0392-0488
IS - 6
ER -