Immunotherapy and biological modifiers for the treatment of malignant brain tumors

Carlo Marras, Carmela Mendola, Federico Giuseppe Legnani, Francesco DiMeco

Research output: Contribution to journalArticlepeer-review

Abstract

The relative ineffectiveness of current therapies for malignant gliomas has led to the need for novel therapeutics. Therapies based on biologic modifiers are among a variety of cancer treatments currently in use or under experimental evaluation and have shown great promise, especially since several potent stimulators of the immune system have been cloned and are now available for clinical use. Early attempts at glioma therapy based on biologic modifiers, however, have failed to demonstrate significant effectiveness. In this review, we select and summarize the results of preclinical and clinical studies published during the past two years that focus on immunotherapy and biologic modifiers for treating gliomas. Despite limited clinical success, we conclude that an increased understanding of molecular biology and immunology from recent studies may pave the way for more effective approaches.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalCurrent Opinion in Oncology
Volume15
Issue number3
DOIs
Publication statusPublished - May 2003

ASJC Scopus subject areas

  • Cancer Research

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